MicroRNA let-7g-5p improves murine collagen-induced arthritis by inhibiting Th17 cell differentiation.

MicroRNA let-7g-5p improves murine collagen-induced arthritis by inhibiting Th17 cell differentiation. Biochem Pharmacol. 2020 Jan 24;:113822 Authors: Yang P, Zhang M, Wang X, Xu AL, Shen M, Jiang B, Zhou X, Zhou L Abstract Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease with complicated pathogenesis. IL-17-producing T helper cells (Th17) are important players in the RA process. Despite numerous researches have proven that microRNAs (miRNAs) were crucial regulators of autoimmune diseases including RA, the effect of miRNAs on the development and function of Th17 cells in the RA progress is not clear. Here, our results showed that the expression of miRNA let-7g-5p was substantially lower in RA patients and CIA mice compared with healthy controls. Furthermore, let-7g-5p could notably suppress the differentiation of Th17 cells in vitro. And the disease severity in CIA mice was significantly alleviated after the treatment of let-7g-5p mimics, accompanied by the deficiency of Th17 cells. These findings indicated that the let-7g-5p could markedly block the differentiation of Th17 cells in RA, which provided a promising target for the clinical therapy of RA. PMID: 31987855 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research