Association of anti-TNF with decreased survival in steroid refractory ipilimumab and anti-PD1 treated patients in the Dutch Melanoma Treatment Registry.

Conclusion Patients experiencing severe ICI toxicity have a prolonged overall survival. However, this survival advantage is abrogated when anti-TNF is administered for steroid-refractory toxicity. Further prospective studies are needed to assess the effect of different immunosuppressive regimens on checkpoint inhibitor efficacy.
PMID: 31988197 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 26, 2020 Category: Cancer & Oncology Authors: Verheijden RJ, May AM, Blank CU, Aarts MJB, van den Berkmortel FWPJ, van den Eertwegh AJM, de Groot JWB, Boers-Sonderen MJ, van der Hoeven JJM, Hospers GA, Piersma D, van Rijn RS, Ten Tije A, van der Veldt AA, Vreugdenhil G, van Zeijl MCT, Wouters MWJM, H Tags: Clin Cancer Res Source Type: research