Successfully treated patients with vortioxetine versus venlafaxine: a simplified cost-effectiveness analysis based on a head-to-head study in asian patients with major depressive disorder.

Conclusions. Higher rates of dual treatment success were seen with vortioxetine versus venlafaxine. Although vortioxetine was not dominant in the base case, the incremental cost per STP for vortioxetine versus venlafaxine were overall within acceptable ranges. These results support the benefits previously reported with vortioxetine versus other antidepressants in broad efficacy, tolerability profile, and cost-effectiveness. PMID: 31990207 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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Authors: Andrade C Abstract Many observational studies have found an association between antidepressant drug prescription during pregnancy and neurodevelopmental disorders such as autism spectrum disorder, attention-deficit/hyperactivity disorder, and intellectual disability. The results of such studies cannot be considered conclusive because of the possible presence of inadequately measured, unmeasured, and unknown confounds. In this context, maternal anemia before or at but not after 30 weeks of gestation was recently associated with an increased risk of all 3 of these neurodevelopmental disorders. Additionally, ...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSION: A short-term, lay-coach-facilitated Tele-BA is a promising intervention for the growing numbers of homebound older adults lacking social connectedness. The intervention holds promise for scalability in programs that already serve homebound older adults. More research is needed to solidify the clinical evidence base, cost-effectiveness and sustainability of Tele-BA delivered by lay coaches for homebound and other older adults. PMID: 32238297 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
AbstractAim of the studyWe assessed the role of personality traits, anxiety, and depression in residual pain among patients who underwent total hip (THA) and knee (TKA) arthroplasty.MethodEighty-three patients (40 THA and 43 TKA) were interviewed pre-operatively (t0); five  days (t1) after surgery; and one (t2), three (t3), six (t4), and 12  months (t5) after surgery. Personality (TCI-R), pain (VAS), anxiety and depression (HADS), quality of life (SF-12), functionality (HHS/KSS), and disability (WOMAC) were evaluated.ResultsPain reduction and functional improvement were reported at t5 (bothp 
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
AbstractPurposeTo assess the relationship between depressive symptoms and self-perceived severity of autonomic dysfunction in patients with multiple system atrophy (MSA).MethodsCross-sectional evaluation of patients with MSA who underwent autonomic testing, Unified MSA Rating Scale (UMSARS)-1 and -2, rating of the presence and severity of depressive symptoms (Zung scale), quality of life (SF-36), body vigilance, anxiety (Spielberger ’s anxiety scale), severity of autonomic dysfunction with the Composite Autonomic Symptoms Score (COMPASS-31), and severity of orthostatic hypotension (OH) symptoms with the Orthostatic H...
Source: Clinical Autonomic Research - Category: Research Source Type: research
Depression affects about 20% of Americans in their lifetime, and is one of the leading causes of disability. The rates of depression are even higher in those with cardiovascular disease (CVD). Depression affects 38% of patients undergoing coronary artery bypass graft surgery, and the risk of depression is three times as high in patients who have experienced a heart attack compared with the general population. Depression also makes it much more likely that CVD patients will be readmitted to the hospital and report heart-related symptoms. Yet much of the time, symptoms of depression in those with CVD go unrecognized. And as ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Health Heart Health Source Type: blogs
This study aims to analyze whether there are subgroups with different trajectories in the main components of SWB (i.e. positive affect, negative affect, and life satisfaction) within the older population, and identify potential determinants of these heterogeneous trajectories. We analyzed data on 1,189 Spanish older adults aged 50  +, collected as part of a nationwide representative longitudinal survey. We used a growth mixture modeling approach to identify heterogeneous trajectories within each SWB component, and logistic and multinomial regressions to explore the associated determinants. In addition to a predomina...
Source: Journal of Happiness Studies - Category: Psychiatry & Psychology Source Type: research
Authors: La Torre D, Della Torre A, Chirchiglia D, Volpentesta G, Guzzi G, Lavano A Abstract Introduction: Major depression (MDD) is the leading cause of years lost to disability worldwide. Pharmacotherapy and psychotherapy are effective treatments in most depressive episodes: but, about the 30% of MDD patients remain symptomatic, and relapse is a common event. Recently, deep brain stimulation (DBS) has emerged as a valid therapeutic option in treatment-resistant depression (TRD) patients.Areas covered: In this paper, the authors summarize the findings of studies focused on these pathophysiologic phenomena and specifi...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
The abnormal allocation of nodules of grey matter in areas of the brain or spinal cord that should physiologically be occupied by white matter characterizes a neural defect called Grey Matter Heterotopia (GMH). The improvement of MRI techniques has enabled a deeper understanding of the neuropathological bases and epidemiology of such a condition. Among its major manifestations, there is the onset of epileptic seizures, mild intellectual disability, impairments in executive functioning, neurodevelopmental disorders; less frequently GMH has been found associated with depression, anxiety, and schizophrenia. Despite the clinic...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: The relatively high prevalence of symptoms of the cervical spine dysfunction, chronic pain, stress, and neck disability among young people may indicate that numerous spinal disorders identified in dentists result not only from their profession, in which spine is significantly overloaded, but also individual predispositions including biopsychosocial profile and the changing lifestyle habits of young people.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study aims to develop an understanding of the s exual health experiences of Italian women 1 year after they experienced AMIs. This qualitative study used Cohen’s phenomenological design. A sample of 12 women was interviewed. Each interview was audio-recorded, and all interviews had a duration ranging from 40 to 60 min. Interviews were read, r e-read, and analyzed by each researcher, who then extrapolated themes. Three main themes emerged from the analysis of the interviews: the fear of a recurring infarction, stress, and the desire to receive information about their recovery. Two sub-themes also emerge...
Source: Sexuality and Disability - Category: Disability Source Type: research
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