Osteocalcin in acute stress response: from the perspective of cardiac diseases.

Osteocalcin in acute stress response: from the perspective of cardiac diseases.
Curr Med Res Opin. 2020 Jan 28;:1
Authors: Tian A, Yang C, Jin Z
Abstract
Osteocalcin is an osteoblast-derived peptide mainly found in the bone matrix but also in circulation. A recent investigation suggested that osteocalcin mediated acute stress response (ASR) by inhibiting parasympathetic tone in mice and humans. We propose a hypothesis that osteocalcin is regulated by the skeleton movement and glucocorticoids, and inhibition of the parasympathetic tone by osteocalcin may indicate a therapeutic target in the treatment of acute myocardial infarction (AMI).
PMID: 31990218 [PubMed - as supplied by publisher]

Source: Current Medical Research and Opinion - January 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research