Geographically distinct North-East Indian Helicobacter pylori strains are highly sensitive to clarithromycin but are levofloxacin resistant

Conclusions: Resistance for clarithromycin was less in North-East Indian strains but high for levofloxacin indicating that first-line therapy may be best and effective for eradication of H. pylori in this region. This study is the first report that showed antibiotic susceptibility pattern for clarithromycin and levofloxacin by mutation analysis. By partial sequencing of 23s rRNA and gyraseA gene, we found that North-East Indian strains are geographically distinct.

Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Shweta Mahant Amresh Kumar Sharma Valentina Gehlot Asish Kumar Mukhopadhyay Ayushi Chhawchharia Sangitanjan Dutta Anil Agarwal Anup Som Kunal Das Rajashree Das Source Type: research