Lung Transplant Pathology

Alloimmune reactions are, besides various infections, the major cause for impaired lung allograft function following transplant. Acute cellular rejection is not only a major trigger of acute allograft failure but also contributes to development of chronic lung allograft dysfunction. Analogous to other solid organ transplants, acute antibody-mediated rejection has become a recognized entity in lung transplant pathology. Adequate sensitivity and specificity in the diagnosis of alloimmune reactions in the lung can only be achieved by synoptic analysis of histopathologic, clinical, and radiological findings together with serologic and microbiologic findings.

Source: Surgical Pathology Clinics - January 29, 2020 Category: Pathology Authors: Christopher Werlein, Allison Seidel, Gregor Warnecke, Jens Gottlieb, Florian Laenger, Danny Jonigk Source Type: research