Connective Tissue Disease Related Interstitial Lung Disease

Patients with connective tissue diseases may have pulmonary involvement, including interstitial lung disease. Various patterns of interstitial lung disease have been classically described in certain connective tissue diseases. It is now recognized that there is significant overlap between patterns of interstitial lung disease observed in the various connective tissue diseases. Differentiating idiopathic from connective tissue disease-related interstitial lung disease is challenging but of clinical importance. New concepts in the diagnosis of connective tissue disease related interstitial lung disease may prove useful in making the diagnosis.
Source: Surgical Pathology Clinics - Category: Pathology Authors: Source Type: research

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To develop a screening tool for the detection of interstitial lung disease (ILD) patterns using a deep-learning method.
Source: Clinical Radiology - Category: Radiology Authors: Source Type: research
Publication date: Available online 15 February 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Lucas L. van den Hoogen, Jacob M. van LaarAbstractTargeted therapies using biological disease-modifying antirheumatic drugs (bDMARDs) and small molecule synthetic drugs have revolutionized rheumatological practice. Initially developed for the treatment of immune arthritis (rheumatoid arthritis, psoriatic arthritis, and spondylarthritis), both bDMARDs and small molecule synthetic drugs are now increasingly entering the space of connective tissue disease (CTD) treatment. Recent clinical trial data in systemi...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsOur study suggests that the CAT can be applied to evaluate the lung ‐specific quality of life in SSc‐ILD similar to in IIP regarding the pulmonary function, but it should be noted pulmonary arterial hypertension in SSc‐ILD influences the CAT score.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
International Journal of Rheumatic Diseases, Volume 23, Issue 2, Page 137-139, February 2020.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: EDITORIAL Source Type: research
Abstract Idiopathic inflammatory myopathies are autoimmune processes that are characterized by skeletal muscle inflammation. The lung is the most commonly involved extramuscular organ and, when present, pulmonary disease drives morbidity and mortality. A subset of patients can present with rapidly progressive hypoxemic respiratory failure due to myositis-related interstitial lung disease. Confirmatory autoantibody testing requires sending samples to a reference laboratory, thus diagnosis of rapidly progressive myositis-associated interstitial lung disease relies on a high index of suspicion and careful history and...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
CONCLUSIONS: This study indicated that the prevalence of ILD was high in CADM. Asymptomatic ILD has been previously underestimated. Anti-MDA5 was a risk factor for the presence of A/SIP, and CYFRA21-1 was a risk factor for ILD. PMID: 32049748 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 7 February 2020Source: Respiratory Medicine Case ReportsAuthor(s): Kota Murohashi, Yu Hara, Ayako Aoki, Masahito Matsumura, Toshiro Kataoka, Koji Okudela, Takeshi KanekoAbstractAn 83-year-old man with a history of interstitial lung disease (ILD) presented with a 1-week history of progressive dyspnea. Computed tomography of the chest revealed right lung-predominant, diffuse, ground glass opacities superimposed upon reticular opacities. Despite methylprednisolone pulse therapy under a diagnosis of acute exacerbation (AE) of ILD, lung involvement and renal dysfunction worsened and disseminat...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionGiven the relatively low incidence of immune ‐related AEs and the comparability of clinical outcomes, ICIs can be treatment option of NSCLC patients with special issues.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation a...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Publication date: February 2020Source: The Lancet Respiratory Medicine, Volume 8, Issue 2Author(s): Christopher J Ryerson, Nicole S L Goh
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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