Levonorgestrel ‐releasing intrauterine system and breast cancer risk: A systematic review and meta‐analysis

ConclusionsCurrent evidence suggests that LNG ‐IUS users have an increased breast cancer risk regardless of age and indication. The effect of LNG‐IUS on breast cancer risk seems to be larger in older users. However, our systematic review detected methodological issues across the available studies, and confounding factors may be responsible for at least a fraction of the risk effects associated with LNG‐IUS use. Nevertheless, users of LNG‐IUS should be aware of these trends. We believe that caution is needed, and risks balanced against proven health benefits (e.g. effective treatment of heavy menstrual bleeding and avoidance of sur gical interventions), when prescribing LNG‐IUS for long periods of use, especially in women with other known breast cancer risk factors such as old age, obesity, and familial predisposition.

Source: Acta Obstetricia et Gynecologica Scandinavica - January 27, 2020 Category: OBGYN Authors: Livia Conz, Bruna Salani Mota, Luis Bahamondes, Ma íra Teixeira Dória, Sophie Françoise Mauricette Derchain, Rachel Rieira, Luis O. Sarian Tags: SYSTEMATIC REVIEW Source Type: research