Hepatitis C Virus Infection in Pregnancy: An Update
Parenteral transmission is the major route of hepatitis C virus transmission in adults; however, vertical transmission is most common in children. There are several factors that have been shown to be associated with vertical transmission of hepatitis C virus, including hepatitis C virus RNA, human immunodeficiency virus coinfection, and peripheral blood mononuclear cell infection. As there is no effective vaccine to prevent hepatitis C virus infection, and there are no human data describing the safety of the new direct acting antiviral agents in pregnancy, the only preventive strategy for vertical transmission is to treat the hepatitis C virus infection before becoming pregnant. Direct acting antiviral agents are interferon-free, and many are also ribavirin-free. Based on animal studies, sofosbuvir plus ledipasvir may be the best safety profile during pregnancy for now; however, it is too early to recommend treating hepatitis C virus-infected pregnant women with these direct acting antiviral agents currently.
Conclusion To improve public health, universal screening of pregnant women for HCV infection should be performed. Early identification of women and children with HCV infection is important to enable them to be included in assessment and/or treatment programs. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | open access Full text
PMID: 32168232 [PubMed - as supplied by publisher]
CONCLUSION: In this cohort, the seroprevalence of HCV antibody was low, and the current risk factors for HCV screening were not identified. These findings may be useful in defining new strategies for identifying mothers with the HCV antibody and the neonates susceptible to maternal transmission of HCV. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT01959321. PMID: 32168224 [PubMed - as supplied by publisher]
Abstract Hepatitis C virus (HCV) infection affects 170 million people worldwide, with at least 5% of individuals with HCV progressing to life-threatening complications, including hepatocellular carcinoma, within 20 years from acute infection. The World Health Organization has called for viral hepatitis elimination as a major public health threat by 2030. The recent development and availability of direct-acting antiviral drugs have been a game-changer in the HCV-treatment paradigm-response exceeds 90%, with minimal adverse events. Accordingly, the U.S. Preventive Services Task Force and the American Association for...
There is worldwide enthusiasm for the elimination of hepatitis C (HCV). The availability of highly effective and safe direct acting anti-viral agents to treat almost everyone with HCV infection means that HCV elimination is now primarily a public health challenge. Making progress towards HCV elimination requires screening to increase the proportion of HCV-infected persons who are aware of their status, linking to and retaining them in care to achieve cure, and increasing access to harm reduction services to prevent new infections.
There is worldwide enthusiasm for the elimination of hepatitis C (HCV). The availability of highly effective and safe direct-acting antiviral agents to treat almost everyone with HCV infection means that HCV elimination is now primarily a public health challenge. Making progress toward HCV elimination requires screening to increase the proportion of HCV-infected persons who are aware of their status, linking to and retaining them in care to achieve cure, and increasing access to harm reduction services to prevent new infections.
ConclusionThis case highlights and adds to the growing body of evidence supporting the need for universal screening for hepatitis C in ICP patients and the potential role for repeat SBA testing, which would be a notable change from the traditional care of these individuals.
Authors: Ifeorah IM, Bakarey AS, Akubo AO, Onyemelukwe FN Abstract Hepatitis C virus (HCV) is associated with liver complicated diseases resulting in end-stage hepatocellular carcinoma. Although vertical transmission from mother to child serves as one of the routes of HCV acquisition in children, yet HCV infection in pregnant women and children is still underappreciated in sub-Saharan Africa. Therefore, this study investigated the burden of HCV, associated risk factors, and viremia among antenatal and postnatal clinic attendees in the rural and urban communities of Kogi State, Nigeria. Atotal of 176 blood samples w...
CONCLUSION: The reported prevalence of maternal HCV infection has increased 161% from 2009 to 2017. PMID: 31923064 [PubMed - as supplied by publisher]
Chronic hepatitis C virus (HCV) infection is characterized by persistent high-level viremia and defective cellular immunity, including a lack of functional HCV-specific CD4+ T cells. We previously described an exceptional period of viral control that occurs in some chronically infected women after childbirth. Here, we investigated whether reduced HCV replication after pregnancy is associated with recovery of CD4+ T cell immunity. Class II tetramer analysis revealed significantly greater frequencies of circulating HCV-specific CD4+ T cells at 3 months postpartum in women with concurrent declines in viremia compared with tho...