Clinical features of Lewy body dementia: insights into diagnosis and pathophysiology
ConclusionsClusters of specific core and supportive DLB features are identified, which together with the evaluated screening instruments evaluated, may inform improved strategies to diagnose DLB in clinical and research settings.
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Publication date: Available online 21 February 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): Ashima Khosla, Padmavati Khandnor, Trilok ChandAbstractElectroencephalogram (EEG) measures the neuronal activities in the form of electric currents that are generated due to the synchronized activity by a group of specialized pyramidal cells inside the brain. The study presents a brief comparison of various functional neuroimaging techniques, revealing the excellent neuroimaging capabilities of EEG signals such as high temporal resolution, inexpensiveness, portability and non-invasiveness as compared to the other ...
CONCLUSION: The results of this study show that BMI and the first-month utilization rate of CPAP treatment are the predictors of the long-term adherence to this treatment. PMID: 32076950 [PubMed - as supplied by publisher]
CONCLUSION: The association between Alzheimer's disease pathology and anxiety and apathy is partly due to impairment in cognitive functioning. PMID: 32088096 [PubMed - as supplied by publisher]
ConclusionThe results of this study show that BMI and the first-month utilization rate of CPAP treatment are the predictors of the long-term adherence to this treatment.
ConclusionThe prevalence of a high risk of OSA in male patients with dizziness is high and a higher risk of OSA is associated with more dizziness-related impairments. A high risk of OSA is not associated with unexplained dizziness or with hyperventilation/anxiety disorders.
Dementia with Lewy bodies (DLB) is the second most common form of dementia in the elderly, and various clinical symptoms, including olfactory dysfunction, dysautonomia, depression, and rapid eye movement sleep behavior disorders (RBD), occur in patients with the prodromal state of DLB. We herein describe a case of a 72-years-old right-handed woman who exhibited primary progressive aphasia (PPA) as a prodromal state of DLB and took cholinesterase inhibitors (donepezil). At 4.5 years after aphasia onset, she exhibited all the core clinical features of DLB, including visual hallucinations, fluctuating cognition, RBD, and Park...
Publication date: Available online 15 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Filip Kosel, Jessica M.S. Pelley, Tamara B. FranklinAbstractTransgenic mouse models have been used extensively to model the cognitive impairments arising from Alzheimer’s disease (AD)-related pathology. However, less is known about the relationship between AD-related pathology and the behavioural and psychological symptoms of dementia (BPSD) commonly presented by patients. This review discusses the BPSD-like behaviours recapitulated by several mouse models of AD-related pathology, including the APP/PS1, Tg2576...
ConclusionContrast sensitivity impairment in drug-na ïve PD patients associates with clinical demand for therapeutic intervention of cognitive decline as well as development of visual hallucinations in the early course of the disease.
This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.