Predicting daytime sleepiness and fatigue: a 9-year prospective study in myotonic dystrophy type 1

This study aimed to determine factors that may influence levels of daytime sleepiness and fatigue in a large cohort of DM1 patients followed for 9 years.MethodsThis study included 115 patients with DM1 at baseline (Time 1,T1) and at Time 2 (T2) who were questioned for daytime sleepiness, fatigue, history of depression, psychological distress, pain, hypothyroidism, and sleep habits. Also, their muscular impairment and intellectual quotient were evaluated. Regression models were used to identify correlates of daytime sleepiness and fatigue while controlling for time effect.ResultsBoth daytime sleepiness and fatigue increased betweenT1 andT2, but their rate of change are higher when CTG repeat number is higher (p 
Source: Journal of Neurology - Category: Neurology Source Type: research

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Authors: Dietrich DE, Bode L, Spannhuth CW, Hecker H, Ludwig H, Emrich HM Abstract BACKGROUND: Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. This called to mind previous evidence for an infectious contribution of BDV-1 to mental disorders. Pilot open trials suggested that BDV-1 infected depressed patients benefitted from antiviral therapy with a licensed drug (amantadine) which also tested sensitive in vitro. Here, we designed a double-blind placebo-controlled randomized clinical trial (RCT) which cross-lin...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
This correction reports and rectifies errors in several articles published in JAACAP between 2009 and 2011. Incorrect coding of the Suicidal Ideation Questionnaire-Jr resulted in the wrong reporting of the means for this measure and of the rate of participants with clinically significant suicidal ideation. The authors would like to apologize to the editorial staff and the readers for these mistakes.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Tags: Correction Source Type: research
Publication date: Available online 19 February 2020Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Anne Barden, Michael Phillips, Emilie Mas, Lisa M. Hill, Ian Mowat, P.S. Loh, Tomas Corcoran, Trevor A. Mori
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
This study was aimed to estimate the prevalence of chronic pain in different regions of China. Data on pain and its treatment were collected from 9357 participants using questionnaires and telephone-based interviews, from 31 regions of China. Gathered data were then coded into electronic data acquisition system and descriptive and inferential statistical analysis was performed. Out of 9298 participants, the ratio of chronic pain was 31.54% with the proportion of male having chronic pain (33.86%) was higher than that of female (29.53%). The average age of participants with pain (45.02 ± 15.07 years) was higher than f...
Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
Publication date: February 2020Source: Infant Behavior and Development, Volume 58Author(s): Elliott Gray Johnson, Janani Prabhakar, Lindsey N. Mooney, Simona GhettiAbstractEpisodic memory, or the ability to remember past events with specific detail, is central to the human experience and is related to learning and adaptive functioning in a variety of domains. In typically developing children, episodic memory emerges during infancy and improves during early childhood and beyond. Developmental processes within the hippocampus are hypothesized to be primarily responsible for both the early emergence and persistence of episodi...
Source: Infant Behavior and Development - Category: Child Development Source Type: research
CONCLUSION: Prison mental health teams face the challenge of identifying prisoners who need mental health services and providing early care to this vulnerable group; this challenge may offer a unique opportunity for intervention among a population that might not otherwise have had access to it. PMID: 32061382 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
PMID: 32068583 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
PMID: 32068588 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
ConclusionsDespite published reports showing benefit for pain control in patients with BPA, the overall low quality, retrospective evidence included in this review highlights the need for a rigorous prospective study to further address this indication.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Review Article Source Type: research
Publication date: Available online 19 February 2020Source: Chemico-Biological InteractionsAuthor(s): Guo-liang Liu, Yun-feng Cui, Chang Lu, Peng ZhaoAbstractKetamine is gaining ground as a potential treating depression because it has a distinct mode of action than typical drugs that influence monoamine neurotransmitters including noradrenaline, dopamine, or serotonin. Ketamine is thought to act by blocking N-methyl-d-aspartate (NMDA) receptors in the brain, which interact with the amino acid neurotransmitter glutamate. The resultant chemical changes in the brain caused by ketamine are not yet fully understood but could inv...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
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