Effects of octreotide on autophagy markers and cell viability markers related to metabolic activity in rat pituitary tumor cells

ConclusionsWe provided evidence that octreotide can affect autophagy in pituitary tumor cells. The observed effects of octreotide were not related to a decrease of cellular metabolic activity. Finally, the induction of autophagy was either short-lived or overshadowed by other factors in the long term and this limit does not help clarifying their real impact on the pharmacological activity of somatostatin analogs.
Source: Pituitary - Category: Endocrinology Source Type: research