Long non-coding RNA GAS5 regulates macrophage polarization and diabetic wound healing

A central feature of diabetic wounds is the persistence of chronic inflammation, which is partly due to the prolonged presence of pro-inflammatory (M1) macrophages. Using in vivo and in vitro analyses, we have tested the hypothesis that lncRNA GAS5 (Growth Arrest-Specific 5) is dysregulated in diabetic wounds. We have assessed the contribution of GAS5 to the M1 macrophage phenotype, as well as the functional consequences of knocking down its expression. We found that expression of GAS5 is significantly increased in diabetic wounds and in cells isolated from diabetic wounds.

Source: Journal of Investigative Dermatology - January 27, 2020 Category: Dermatology Authors: Junyi Hu, Liping Zhang, Cole Liechty, Carlos Zgheib, Maggie M. Hodges, Kenneth W. Liechty, Junwang Xu Tags: Original Article Source Type: research