Enhanced glycogen metabolism supports the survival and proliferation of HPV-infected keratinocytes in condylomata acuminata

Condylomata acuminata (CA) is caused by HPV infections of keratinocytes and is a common sexually transmitted disease. The main clinical feature and risk of CA is the high recurrence of genital warts formed by infected keratinocytes. Metabolic reprogramming of most types of mammalian cells including keratinocytes can provide energy and intermediates essential for their survival. Here we report that HPV infection develops a hypoxic microenvironment in CA warts, inducing the accumulation of glycogen and increased glycogen metabolism in the infected keratinocytes in a HIF-1 α dependent pathway.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research