AURKA Enhances Autophagy of ADSCs to Promote Diabetic Wound Repair via Targeting FOXO3a

AURKA (Aurora kinase A) regulates apoptosis and autophagy in a diverse range of disease and exhibited a promising clinical efficacy. But the role of AURKA in regulating ADSCs (Adipose derived stem cells) repairing diabetic wound remains unclear. Here, we showed that ADSCs subjected to high glucose stress displayed an obvious induction of AURKA, FOXO3a and a significant increase in autophagy and apoptosis. The AURKA was confirmed to regulate autophagy through FOXO3a. AURKA mediated autophagy inhibited high glucose-induced apoptosis of ADSCs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research