Monte Carlo simulation of non-target organ doses and radiation-induced secondary cancer risk in Tanzania from radiotherapy of nasopharyngeal by using Co-60 source

This study was designed to assess non-target organ doses from Co-60 teletherapy for patients with nasopharyngeal cancer and to estimate the risk of radiation-induced secondary cancer. Specific organ-absorbed doses were evaluated in anatomically realistic 15-year-old and adult male phantoms based on Monte Carlo simulation. The assessed organ doses were used to calculate the lifetime secondary cancer risks in non-target organs according to the BEIR VII risk models. Survival information and the baseline cancer risks were associated with statistical data for the Tanzanian population. The average absorbed doses in non-target organs depended heavily on the distance from the target isocentre and patient's age. Organs near the tumour target, such as the salivary glands, brain, thyroid glands, eye bulb and oesophagus, received very high absorbed doses. The absorbed doses decreased exponentially towards the testis and prostate which are far from the tumour target. The highest received absorbed doses in non-target organs were due to the leakage in the gantry head and scattered radiation from collimator and inside the patient body. The absorbed doses were higher for young patients than in adults because of the larger body area exposed to high-dose radiation. The lifetime attributed risks for all organs considered were relatively lower than the baseline cancer risks. Results can help provide future database about radiation-induced second primary cancer incidence after Co-60 external beam ...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research