Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy

This study suggests that the NR4A1/DNA-PKcs/p53 pathway is involved in the mechanism by which lactate accelerates vascular calcification, partly through excessive Drp-mediated mitochondrial fission and BNIP3-related mitophagy deficiency.

http://link.springer.com/10.1007/s10495-020-01592-7

Source: Apoptosis - January 27, 2020 Category: Molecular Biology Source Type: research