Functional roles of V-ATPase in the salivary gland

Conclusion An increasing number of studies reveal that the immunoreactivity of V-ATPase is restricted to ductal cells with species- and gland-specific distribution, and that different subunit isoforms of V-ATPase could be involved in targeting it to various intracellular locations. Considering that the major function of salivary gland duct epithelial cells is the reabsorption of Na+ and Cl−, and secretion of K+ and HCO 3 − , V-ATPase may primarily function in transporting protons out of cells across the plasma membrane, or acidifying compartments, resulting in modifying fluid and electrolyte transport.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research