Late ‐Onset Hypogonadism and Lifestyle‐Related Metabolic Disorders

ConclusionsEmerging new evidence suggests that metabolic disorders may aggravate LOH effects on the fertility potential of males in reproductive age, by enhancing T deficiency. These results clearly show that metabolic disorders, such as obesity and diabetes, have a greater impact on causing hypogonadotropic hypogonadism than tissue senescence. Further, TRT and off ‐label alternatives capable of restoring T levels appear as suitable to improve LOH, while also counteracting comorbidities related with metabolic diseases.

Source: Andrology - January 27, 2020 Category: Urology & Nephrology Authors: Patr ícia C. Braga, Sara C. Pereira, João P. Ribeiro, Mário Sousa, Mariana P. Monteiro, Pedro F. Oliveira, Marco G. Alves Tags: REVIEW ARTICLE Source Type: research