Early Feasibility Study: Fetoscopic NEOX Cord 1K ® Myelomeningocele (MMC) Repair

Conditions:   Spina Bifida;   Fetus Risk;   Myelomeningocele Intervention:   Device: NEOX Cord 1K applied fetoscopically Sponsor:   The University of Texas Health Science Center, Houston Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Conditions:   Spina Bifida;   Fetus Risk;   Myelomeningocele Intervention:   Device: NEOX Cord 1K applied fetoscopically Sponsor:   The University of Texas Health Science Center, Houston Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The primary goal of fetal surgery for spina bifida is reduction in postnatal treatment of hydrocephalus. Reversal of hindbrain herniation is considered an important antecedent for improved cerebrospinal fluid dynamics and a sign of neurosurgical success. The aim of this study is to evaluate prenatal ventricular size and hindbrain herniation (HBH) after fetoscopic spina bifida repair and relate it to postnatal outcome.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session III Source Type: research
Fetoscopic spina bifida (SB) repair under humidified-warmed Partial-Amniotic-Carbon-dioxide-Insufflation (hw-PACI) is being clinically implemented without preclinical validation, yet with promising preliminary results. We experimentally assessed the safety and feasibility of hw-PACI for fetoscopic anatomical SB repair.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
Fetal repair of an open neural tube defect by hysterotomy has been shown to reduce the need for shunting and improve motor outcomes for infants, but increases the risk of cesarean section and prematurity. Fetoscopic repair is an alternate approach that has shown to be safe, may confer similar benefits, and reduces the incidence of complications. We sought to compare the cost of the two approaches, from fetal surgery until neonatal discharge.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
The objectives were: 1) To evaluate the incidence of CAS after prenatal MMC repair; 2) To determine risks factors associated with its occurrence; 3) To study those outcomes associated with CAS after prenatal MMC repair. METHODS: Retrospective cohort study of 91 patients that underwent fetal MMC repair between November 2011 and December 2018. Surgery was performed using either a fetoscopic (laparotomy and exteriorized uterus) approach or an open-hysterotomy approach. Eligibility criteria were as reported in the Management of Myelomeningocele Study (MOMS). If CAS was detected by US, its' severity was graded as: "Mi...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Abstract OBJECTIVES: We previously reported on a fetoscopic repair for open neural tube defect (ONTD) using a single layer closure (SLC). Because of a high rate of cerebrospinal fluid (CSF) leak at birth we developed a 3 layer closure (3LC) comprising a bovine collagen patch, a myofascial layer and a skin layer, using the same exteriorized uterus, fetoscopic technique. METHODS: Prospective cohort study: 32 consecutive SLC controls were compared with 18 consecutive 3LC cases. All patients satisfied Management of Myelomeningocele Study (MOMS) criteria. Obstetric, maternal, fetal, and early neonatal outcomes wer...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Some recent things...ResearchBeing ‘A Google Mom’ or Securely Monitored at Home: Perceptions of Remote Monitoring in Maternity CareJournal of Advanced Nursing, a study from FinlandMulticultural coping experiences of parents following perinatal loss: A meta ‐ethnographic synthesisJournal of Advanced Nursing, a study from SpainNICENICEimpact: maternity and neonatal careA report on the impact of NICE guidance on maternity and neonatal care.NICE are consulting on prenatal repair for open neural tube defects in the fetus -fetoscopic repair  andopen repair . Mental healthCentre for Mental HealthAn economi...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
CONCLUSIONS: The authors' preliminary results suggest that fetoscopic treatment of MMC is feasible, reproducible, and safe for mothers and their babies. Neurological outcomes were favorable and similar to those in the available literature. As known, prematurity was the greatest complication. PMID: 31574466 [PubMed - in process]
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
CONCLUSIONS: Although the efforts of further advancement of intrauterine prenatal MMC repair aim to increase neonatal outcomes, maternal health hazard will continue to be an issue of crucial importance and further studies are required. PMID: 31574465 [PubMed - in process]
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
CONCLUSIONS: The survey results showed diversity in the management of patients with MMC. In addition, significant diversity remains regarding fetal surgery for MMC closure. Despite the apparent benefits of open fetal surgery in selected pregnancies, only a minority of centers and providers offer this technique. As a more technically demanding technique that requires multidisciplinary effort with less well-established long-term outcomes, fetoscopic surgery may face similar limited implementation, although the surgery may pose fewer maternal risks than open fetal surgery. Centralization of prenatal treatment to tertiary care...
Source: Neurosurgical Focus - Category: Neurosurgery Authors: Tags: Neurosurg Focus Source Type: research
More News: Fetoscopy | Gastroschisis Repair | Research | Science | Study | Texas University