Endometrial cancer prevention in high-risk women

Publication date: Available online 20 December 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Kelechi Njoku, Joanna Abiola, Johanna Russell, Emma J. CrosbieAbstractEndometrial cancer (EC) is the most common gynaecological malignancy, and its incidence is rising alongside the growing prevalence of obesity. Effective risk-reducing interventions hijacking the key mechanisms driving endometrial carcinogenesis may affect EC diagnoses if aimed at those at greatest risk. An understanding of the key risk factors and their role in tumourigenesis is critical in developing such prevention strategies. In this review, we summarise the major risk factors for EC and the evidence for available risk-reducing interventions in high-risk women. We suggest potential prevention strategies and make a case for the need for risk prediction models that identify specific groups of women at a particularly high risk of EC for whom risk-reducing interventions are likely to have a significant impact.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research

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Conditions:   Endometrial Cancer;   Obesity;   Endometrial Intraepithelial Neoplasia Intervention:   Behavioral: Referral to Center for Metabolic and Bariatric Surgery Sponsors:   Brigham and Women's Hospital;   Dana-Farber Cancer Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Our data support the adoption of the surgical management of the morbidly obese patient. Although short term complication rates are higher with increasing obesity (II-III class), a majority of procedures can still be completed with minimally invasive approach. PMID: 32064825 [PubMed - in process]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
This study demonstrates a need for patient education regarding the strong relationship between obesity and endometrial cancer risk. Patients are willing to consider weight loss interventions if they were proven to be as safe and effective as pelvic surgery in the management of endometrial cancer.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Conditions:   Endometrial Cancer;   Extreme Obesity Intervention:   Procedure: Transvaginal natural orifice endoscopic surgery for endometrial cancer staging Sponsor:   Dr. Lutfi Kirdar Kartal Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, all patients with DM should be undergo recommended age- and sex appropriate cancer screenings to promote primary prevention and early detection. Furthermore, cancer should be screened in routine diabetes assessment. PMID: 31902143 [PubMed - in process]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
Publication date: Available online 2 January 2020Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): A. Gentry-Maharaj, C. KarpinskyjAbstractDue largely to the rise in obesity and prolonged life expectancy, endometrial cancer rates have increased by 56% since the early 90s. Women at high risk (Lynch Syndrome) have a 12-47% lifetime risk of developing endometrial cancer and professional societies recommend annual surveillance using transvaginal ultrasound (TVS) and endometrial biopsy (outpatients hysteroscopy) from age 30-35 with hysterectomy from age 40. In women at low risk, screening is not...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
This article also reviews bariatric surgery and endometrial cancer as well as new updates in radiation, chemotherapy and hormonal therapy research in the obese population. Summary The current article reviews therapeutics and surgery in the morbidly obese for the treatment of endometrial cancer.
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: GYNECOLOGIC CANCER: Edited by Gottfried E. Konecny Source Type: research
This study investigated protein expression in endometrial cancer and benign tissue and its correlation with obesity and insulin resistance.One hundred and seven women undergoing hysterectomy for endometrial cancer or benign conditions provided a fasting blood sample and endometrial tissue. We performed proteomic expression according to body mass index, insulin resistance, and serum marker levels.
Source: Translational Research - Category: Research Authors: Source Type: research
This study investigated protein expression in endometrial cancer and benign tissue and its correlation with obesity and insulin resistance. One hundred and seven women undergoing hysterectomy for endometrial cancer or benign conditions provided a fasting blood sample and endometrial tissue. We performed proteomic expression according to body mass index, insulin resistance, and serum marker levels. We used linear regression and independent t test for statistical analysis. Proteomic data from 560 endometrial cancer cases from The Cancer Genome Atlas (TCGA) databank were used to assess reproducibility of results. One hundred ...
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Tags: Transl Res Source Type: research
This study investigated protein expression in endometrial cancer and benign tissue and its correlation with obesity and insulin resistance.107 women undergoing hysterectomy for endometrial cancer or benign conditions provided a fasting blood sample and endometrial tissue. We performed proteomic expression according to body mass index (BMI), insulin resistance and serum marker levels.
Source: Translational Research - Category: Research Authors: Source Type: research
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