β-adrenoreceptors and the risk of Parkinson's disease

Publication date: Available online 27 January 2020Source: The Lancet NeurologyAuthor(s): Franziska Hopfner, Günter U Höglinger, Gregor Kuhlenbäumer, Anton Pottegård, Mette Wod, Kaare Christensen, Caroline M Tanner, Günther DeuschlSummaryBackgroundβ-adrenoceptors are widely expressed in different human organs, mediate important body functions and are targeted by medications for various diseases (such as coronary heart disease and heart attack) and many β-adrenoceptor acting drugs are listed on the WHO Model List of Essential Medicines. β-adrenoceptor antagonists are used by billions of patients with neurological disorders, primarily for the treatment of migraine and action tremor (mainly essential tremor), worldwide.Recent developmentsAn observational study reported a link between the chronic use of the β-adrenoceptor antagonist propranolol and an increased risk of Parkinson's disease, while the chronic use of the β-adrenoceptor agonists was associated with a decreased risk. Further support of this association was provided by a dose-dependent decrease in the risk of Parkinson's disease with chronic β-adrenoceptor agonist (eg, salbutamol) use, and by functional data indicating a possible underlying molecular mechanism. Five additional epidemiological studies have examined the modulation of the risk of Parkinson's disease as a result of the use of β-adrenoceptor-acting drugs in different populations. Overall, similar e...
Source: The Lancet Neurology - Category: Neurology Source Type: research

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CONCLUSIONS: We found DEGs and DEMs in FM patients through bioinformatics analysis, which may be involved in the occurrence and development of FM and serve as potential targets for diagnosis and treatment. PMID: 32083545 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Publication date: Available online 22 February 2020Source: NeuroImageAuthor(s): Ima Trempler, Paul-Christian Bürkner, Nadiya El-Sourani, Ellen Binder, Paul Reker, Gereon R. Fink, Ricarda I. SchubotzAbstractThe brain's sensitivity to and accentuation of unpredicted over predicted sensory signals plays a fundamental role in learning. According to recent theoretical models of the predictive coding framework, dopamine is responsible for balancing the interplay between bottom-up input and top-down predictions by controlling the precision of surprise signals that guide learning.Using functional MRI, we investigated whether ...
Source: NeuroImage - Category: Neuroscience Source Type: research
Authors: Valentí V, Cienfuegos JA, Becerril Mañas S, Frühbeck G Abstract Bariatric-metabolic surgery is the safest, most effective and long-lasting treatment for obesity and its associated co-morbidities, whether they be metabolic (type 2 diabetes, hyperlipidemia non-alcoholic fatty liver disease) or cardiovascular (myocardial infarction, stroke). Due to the obesity pandemic, bariatric-metabolic surgery is the second most frequent intra-abdominal procedure and the gastroenterologist and the surgeon must be aware of the physiologic changes caused by the anatomic reconfiguration following surgery. ...
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
A HEART attack is a frightening prospect, but it does happen. Often, actually. The British Heart Foundation reports 280 people every day are admitted to hospital because of one. How could your left arm be warning you of the deadly condition?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: This case indicates the need for early diagnosis and multidisciplinary action to achieve satisfactory quality of life in patients with 18q- syndrome. PMID: 32087092 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Authors: Abstract Here we present the case of a 50-year-old woman with acute urinary retention who was treated by the insertion of a permanent catheter. For associated headaches, fever and muscle and joint pain, the patient underwent neurologic examination, including lumbar puncture and magnetic resonance of head and spine. The results confirmed aseptic meningitis. Subsequently, the patient was hospitalized at the infectious disease clinic, where the permanent catheter was extracted after 5 days, with spontaneous micturition recovery and no post-void residual volume. The combination of aseptic meningitis and urina...
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
We reported the case of a patient diagnosed with DLGNT who presented with language developmental delay and positive but subtle changes in imaging two years before the emergence of typical clinical symptoms. Few studies were conducted on early tumor symptoms due to the limited number of cases. We hypothesized that with the existence of pre-tumor symptoms, language developmental delay may be related to tumor. PMID: 32087090 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Conclusion: The antimigraine effect of DCXF could be achieved by improving the metabolic profile and increasing the expressions of GS and EAAT1 to promote the glutamate cycle of TCC and serum samples in NTG-induced migraine rats to a certain extent. PMID: 32082393 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
When people experience a significant loss, such as the death of a spouse or child, shock and pain may make them feel like there is no hope for a normal existence ever again. Life has been altered in ways that cannot be “fixed.” Coping skills can help build a comforting sense of routine. They allow introspection and exploration of what happened from different viewpoints. Emotions that flood through the mind can be captured and examined instead of looping endlessly without resolution. Most importantly, they provide help in getting those emotions and conflicting thoughts out instead of keeping them inside where th...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Grief and Loss Mindfulness Self-Help Bereavement grieving Source Type: blogs
Publication date: Available online 21 February 2020Source: NeurocomputingAuthor(s): Xuchu Wang, Suiqiang Zhai, Yanmin NiuAbstractAccurate left ventricle landmark localization in cardiac MRI plays a vital role in computer-aided diagnosis of heart disease. Typical classification models hardly deal with artifacts and low discrimination of landmark regions by using only local image information, while regression models suffer from ambiguity between random samples and label, also the imbalance of samples. To overcome this limitation, this paper proposes a left ventricle landmark localization and identification method in cardiac ...
Source: Neurocomputing - Category: Neuroscience Source Type: research
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