Multiple-Ascending Dose Study in Healthy Subjects to Assess the Pharmacokinetics, Tolerability, and CYP3A4 Interaction Potential of the T-Type Calcium Channel Blocker ACT-709478, A Potential New Antiepileptic Drug

ConclusionsACT-709478 exhibits good tolerability up to 100  mg once daily using an up-titration regimen and pharmacokinetic properties that support further clinical investigations. A weak induction of gastrointestinal cytochrome P450 3A4 activity was observed, unlikely to be of clinical relevance.ClinicalTrials.gov IdentifierNCT03165097.
Source: CNS Drugs - Category: Neurology Source Type: research

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ConclusionThe present study demonstrated that closure of the widely opened frontal sinus using DuraGen inserted between the skull and the pericranium flap is an effective and promising method for the frontal sinus isolation.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Conclusion: Large prospective studies that accurately predict factors that are associated with poor outcomes, determine the pathophysiology, and targeted therapy are required.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Abstract NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend it offers excellent biocompatibility and higher permeation across physiological membranes like BBB. Moreover, the surface of NLC can be easily modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. NLC has found various applications in treat...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
CONCLUSION: MWA may be associated with reversible lesions of the corpus callosum. PMID: 32048282 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
CONCLUSION: In healthy volunteers, no evidence of withdrawal syndrome was found with abrupt discontinuation of short-term treatment with CBD. PMID: 32036242 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
CONCLUSION: These findings reveal an increase in metabolism in the motor cortex during general cortical dysfunction in the frontal and occipital cortices in SHM. Key words: FDG-PET, hemiplegic migraine, migraine, positron emission tomography, SISCOM. PMID: 32002978 [PubMed - in process]
Source: Acta Neurologica Taiwanica - Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Anticonvulsant medications are used in the treatment of epilepsy as neuropathic pain, migraine and psychiatric illness. Anticonvulsants suppress neuronal excitation to reduce the likelihood of seizure activity. Generally, management is supportive with correction of physiological and metabolic parameters. Drug concentrations may help guide specific treatments such as l-carnitine (for valproate) and multiple dose activated charcoal (for carbamazepine, phenytoin, phenobarbital) Extracorporeal treatments may be used to enhance elimination.
Source: Medicine - Category: Internal Medicine Authors: Tags: Poisonous substances Source Type: research
CONCLUSION: These results indicate that this repetitive dosing valproate sodium protocol is a safe and well-tolerated intervention for the treatment of chronic migraine resistant to oral medications. Given the promising outcomes on patient headache improvement with this small pilot study, studies to confirm this benefit in a larger cohort of chronic migraine patients are warranted, preferable with the addition of a blinded control group for comparison. PMID: 31985052 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): J. Eric Piña-Garza, William Rosenfeld, Kazunori Saeki, Vicente Villanueva, Harumi Yoshinaga, Anna Patten, Betsy Williams, Manoj MalhotraAbstractObjectiveThis post hoc analysis of six randomized, double-blind, Phase II and III studies evaluated efficacy and safety of adjunctive perampanel (2–12 mg/day) in adolescent patients (aged ≥ 12 to ≤ 17 years) with uncontrolled partial-onset seizures, with or without secondarily generalized (SG) seizures, or primary generalized tonic–clonic (PGTC) seizures.M...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
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