A mitochondrial root to accelerated ageing and frailty

Nature Reviews Endocrinology, Published online: 28 January 2020; doi:10.1038/s41574-020-0319-yA discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research