FDA strengthens warning that untreated constipation caused by schizophrenia medicine clozapine (Clozaril) can lead to serious bowel problems
FDA warns that untreated constipation caused by schizophrenia drug clozapine (Clozaril) can get worse and lead to serious bowel problems that might require hospitalization or even cause death
Listen to an audio podcast of the January 28, 2020 FDA Drug Safety Communication that FDA is strengthening an existing warning that constipation caused by the schizophrenia medicine clozapine (Clozaril, Fazaclo ODT, Versacloz, generics) can, uncommonly, progress to serious bowel complications.
This study reports a case of concurrent hepatotoxicity and neutropenia induced by clozapine. The patient was a 58-year-old man who started taking clozapine for the first time in March 2017, about seven weeks before his recent admission, because of a history of treatment-resistant schizophrenia. He had been referred to the emergency department of a general hospital with symptoms of weakness, lethargy, fever, and chills. The laboratory results showed neutropenia with a frequency of 352 × 103 (17.5%) and hepatotoxicity with alanine transferase (ALT) = 139 u/L, aspartate transferase (AST) = 214 u/L, total bilirubin = 11....
The FDA on Tuesday issued anupdated warning that constipation caused by the antipsychotic clozapine may increase the risk of serious bowel complications in some patients.Constipation is already an identified side effect of clozapine, but “serious and fatal events continue to be reported,” according to the FDA’swebsite. The medication affects how the intestines function in most patients, and an uncommon but serious problem is complete blockage of the bowel. The risk is greater with clozapine compared with other schizophrenia medications, the FDA wrote.Higher doses of clozapine and the use of clozapine in c...
The agency said that constipation, a common side effect of the popular schizophrenia medication, could progress to serious bowel complications, including complete bowel blockage, if not treated.News Alerts
FDA is strengthening an existing warning that constipation caused by the schizophrenia medicine clozapine (Clozaril, Fazaclo ODT, Versacloz, generics) can, uncommonly, progress to serious bowel complications. This can lead to hospitalization or even death if constipation is not diagnosed/treated.
Conclusions: A high proportion of patients treated with clozapine experience CIGH, presenting most commonly as constipation. Whilst potentially life-threatening, CIGH can be successfully treated in an acute inpatient setting. Active monitoring of CIGH symptoms in patients initiated, or reinitiated on clozapine is recommended.Key pointsA high proportion of patients treated with Clozapine experience constipation, the cardinal feature of Clozapine Induced Gastrointestinal Hypomotility.Whilst potentially life-threatening, CIGH can be successfully treated in an acute inpatient setting with simple interventions.Active monitoring...
Condition: Randomized Controlled Trial Intervention: Other: Baduanjin program Sponsors: National Yang Ming University; Tri-Service General Hospital Completed