What Can We Learn from Canine Atopic Dermatitis History?

AbstractPurpose of ReviewUnderstanding the origin and shaping the current knowledge of canine atopic dermatitis (cAD) with an emphasis on its similarities and differences with its human counterpart, human atopic dermatitis (hAD), has been the purpose of this study.Recent FindingFundamental research on the ethiopathogenesis and recent specific therapeutic findings have gradually reclassified cAD from a single disease to a multifactorial syndrome.SummaryFrom first being referred to as “red mange” or “canine eczema” in a dog reacting to ragweed pollen, cAD has then been considered to be the canine counterpart of hAD. Both conditions share comparable historical discoveries as well as treatment evolutions such as skin barrier defects, the use of cyclosporine, proactive topic al corticosteroids, or recent use of biotherapies. More recent discoveries have however shown some fundamental differences between both conditions such as the place of flea infestation andMalassezia infections in the dog or the hygiene theory in human. As in human medicine*, cAD is also a source of conceptual and nosological remaining controversies.
Source: Current Dermatology Reports - Category: Dermatology Source Type: research