Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation.

Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation.
Annu Rev Med. 2020 Jan 27;71:137-148
Authors: Schwabkey ZI, Jenq RR
Abstract
The microbiome is an integrated part of the human body that can modulate a variety of disease processes and affect prognosis, treatment response, complications, and outcomes. The importance of allogeneic hematopoietic cell transplantation in cancer treatment has resulted in extensive investigations on the interaction between the microbiome and this treatment modality. These investigations are beginning to lead to clinical trials of microbiome-targeted interventions. Here we review some of these discoveries and describe strategies being investigated to manipulate the microbiome for favorable outcomes, such as the proper selection and timing of antibiotics, type of diet and route of administration, probiotics, prebiotics, and fecal microbiota transplantation.
PMID: 31986084 [PubMed - in process]

Source: Annual Review of Medicine - January 26, 2020 Category: General Medicine Authors: Schwabkey ZI, Jenq RR Tags: Annu Rev Med Source Type: research