Role of viruses in asthma

AbstractRespiratory viral infections are the most important triggers of asthma exacerbations. Rhinovirus (RV), the common cold virus, is clearly the most prevalent pathogen constantly circulating in the community. This virus also stands out from other viral factors due to its large diversity (about 170 genotypes), very effective replication, a tendency to create Th2-biased inflammatory environment and association with specific risk genes in people predisposed to asthma development (CDHR3). Decreased interferon responses, disrupted airway epithelial barrier, environmental exposures (including biased airway microbiome), and nutritional deficiencies (low in vitamin D and fish oil) increase risk to RV and other virus infections. It is intensively debated whether viral illnesses actually cause asthma. Respiratory syncytial virus (RSV) is the leading causative agent of bronchiolitis, whereas RV starts to dominate after 1  year of age. Breathing difficulty induced by either of these viruses is associated with later asthma, but the risk is higher for those who suffer from severe RV-induced wheezing. The asthma development associated with these viruses has unique mechanisms, but in general, RV is a risk factor for lat er atopic asthma, whereas RSV is more likely associated with later non-atopic asthma. Treatments that inhibit inflammation (corticosteroids, omalizumab) effectively decrease RV-induced wheezing and asthma exacerbations. The anti-RSV monoclonal antibody, palivizumab,...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research

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CONCLUSION: The design results revealed that an optimum exposure of 1:2 of isopropanol: formaldehyde vapours for sixty minutes resulted in desired release of second pulse of dose after a predetermined lag time of 5 hours as desired. '3Cap' system was successful in achieving floating and pulsed release of hypertensive drug opening a 'new lease of life' to the existing drug molecule. PMID: 32484113 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
This study aimed to investigate the use of the Internetby pregnant women to search for information about pregnancyand childbirth. This study was conducted in Kerman, Iran. Threehundred eighty-five pregnant women waiting for their appointmentswith obstetricians/gynecologists participated in the survey byfilling out a questionnaire. The most common searched topicswere nutrition in pregnancy (81%), fetal development (67%), andcomplications of pregnancy (49%). The most popular sources ofinformation were physicians (61%), the Internet (51%), and printedsources (41%), respectively. More than half of the participantsdid not share...
Source: Informatics for Health and Social Care - Category: Information Technology Tags: Inform Health Soc Care Source Type: research
Effect of Different Antioxidants on X-ray Induced DNA Double-strand Breaks Using γ-H2AX in Human Blood Lymphocytes. Health Phys. 2020 Jul;119(1):101-108 Authors: Bicheru NS, Haidoiu C, Călborean O, Popa A, Porosnicu I, Hertzog R Abstract Ionizing radiation exposure produces direct or indirect biological effects on genomic DNA. The latter are ionizing radiation mediated by induction of free radicals and oxygen species (ROS). The study was conducted to evaluate the dose-effect/time-effect of antioxidant treatments in reducing the induction of double-strand breaks in human blood lymphocytes. Human...
Source: Health Physics - Category: Physics Authors: Tags: Health Phys Source Type: research
Abstract Low-dose radiation effects were studied in Ukrainian personnel of the Chernobyl exclusion zone. The aim of this study was to determine the influence of borderline exposure to annual professional limits and age on expression of molecular markers. Study groups included 300 radiation workers performing construction work on the New Safe Confinement (Arch) upon the Chernobyl "Shelter" [external dose, 26.1 ± 18.1 mSv; age, 43.1 ± 10.3 y overall and 48.7 ± 5.9 y for 69 control persons]. Methods included gene expression using RT-PCR, flow cytometry of lymphocyte antigens, gamma-H2AX...
Source: Health Physics - Category: Physics Authors: Tags: Health Phys Source Type: research
Publication date: Available online 2 June 2020Source: Fish &Shellfish ImmunologyAuthor(s): Po-Tsang Lee, Thi Hang Ho, Bao Trung Nguyen, Yu-Lin Lin, Po-Yu Chiu
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Hey, sorry if this has been addressed but I'm curious as to what other science makes up on the dental application?? On the ADEA AADSAS they mention biomechanics, exercise science, kinesiology, ect... Do these really count towards other sciences? O was a kineisiology major so otd be a huge plus but have a hard time believing I'd be that lucky. Thanks! BTW I've taken, sports psych, biomechanics, exercise physiology, nutrition and wellness, intro to KNS, motor development, motor learning... Other sciences? sGPA
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Dental Source Type: forums
Authors: Kim H, Kwon GE, Kim YH, Callaway Z, Han YS, Seo JJ, Jiao F, Kim CK Abstract Objective: Eosinophil-derived neurotoxin (EDN) is associated with recurrent wheezing episodes after bronchiolitis, childhood asthma, and allergic rhinitis. We investigated if there is a measurable difference between serum EDN levels in children with wheezing and non-wheezing respiratory infections. Methods: 171 children who visited a university hospital with respiratory infections were enrolled in the study. Subjects were divided into two groups: wheezing (n = 46) and non-wheezing (n = 125). Serum EDN le...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
BOSTON (CBS) — When your child is coughing, it can be hard, even for a doctor, to distinguish between a cold or something more serious but researchers in Australia were able to reliably pinpoint the cause of a child’s cough using a smartphone app. Kids cough all the time, often from the common cold or seasonal allergies but sometimes it’s more serious like pneumonia. Kids may be misdiagnosed or treated unnecessarily with antibiotics or other medications because it’s often hard to tell what their coughing is about. Researchers were able to train speech recognition technology to recognize different co...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Dr. Mallika Marshall Source Type: news
ConclusionThese results show that a wide range of HRV serotypes with different levels of nucleotide variation were present in Kenya. Furthermore, our data show that HRVs contributed substantially to influenza‐like illness in Kenya in 2008.This article is protected by copyright. All rights reserved.
Source: Influenza and Other Respiratory Viruses - Category: Virology Authors: Tags: Original Article Source Type: research
Conclusions: HRV was frequently present in hospitalized children with lower respiratory tract infections in Chongqing, China. The disease severity for HRV-C and HRV-A was similar. A high load of HRV-A in the lower respiratory tract might be connected with disease severity in children younger than 2 years.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
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