Organotypic Culture Models for Predictive Toxicology Center

Funding Opportunity Number: EPA-G2013-STAR-L1 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: EnvironmentCFDA Number: 66.509Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: EPAClosing Date: Jan 23, 2014Award Ceiling: $6,000,000Expected Number of Awards: 3Creation Date: Sep 24, 2013Funding Opportunity Description: The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications for research centers to investigate toxic effects of chemical substances in three-dimensional (3D) in vitro models, hereafter referred to as ‘organotypic culture models’ (OCMs). OCMs are tissue culture models that mimic in vivo tissue architecture through interactions of heterotypic cell types (e.g., epithelium-stroma) and extracellular matrices (ECM). They can be established from isolated cells or from tissue fragments harvested in vivo, and will bridge the gap between conventional monolayer cell cultures and whole-animal systems. EPA is interested in the potential application of OCMs that mimic complex cell arrangements and physiologies, scalable from mid to higher throughput screening (HTS), and high-content screening (HCS) approaches. This solicitation seeks the formation of research centers that will guide the development and evaluation of OCMs that will accelerate transl...
Source: Grants.gov - Category: Research Tags: Environment Source Type: funding