Leukocyte profiles in blood and CSF distinguish neurosarcoidosis from multiple sclerosis

Distinguishing neurosarcoidosis (NS) from multiple sclerosis (MS) remains challenging and available parameters lack discriminatory power. Comprehensive flow cytometry data of blood and CSF leukocytes of patients with NS (n  = 24), MS (n = 49) and idiopathic intracranial hypertension (IIH, n = 52) were analyzed by machine learning algorithms. NS featured a specific immune cell pattern with increased activated CD4+ T cells in CSF and increased plasma cells in blood. Combining blood and CSF parameters improve d the differentiation.

Source: Journal of Neuroimmunology - January 26, 2020 Category: Allergy & Immunology Authors: Michael Heming, Lisa Lohmann, Andreas Schulte-Mecklenbeck, Tobias Brix, Catharina C. Gross, Heinz Wiendl, Luisa Klotz, Gerd Meyer zu H örste Source Type: research