Nasal Polyposis and Aspirin-Exacerbated Respiratory Disease
Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic chronic rhinosinusitis with nasal polyps, asthma, and upper-/lower-respiratory tract reactions to nonsteroidal antiinflammatory drugs. Persistent, severe disease, anosmia, and alcohol sensitivity is typical. AERD is mediated by multiple pathways, including aberrant arachidonic acid metabolism leading to elevated leukotriene E4 and decreased prostaglandin E2. Mast cell mediators (prostaglandin D2) and unique properties of eosinophils and type 2 innate lymphoid cells, along with receptor-mediated signaling, also contribute to AERD pathogenesis. Pharmacologic therapies are a cornerstone of AERD treatment and include leukotriene modifiers, corticosteroids, biologics, and aspirin.
Is it time to change our public health message and suggest that everyone wear a mask? Dr Amy Baxter offers her arguments in support of change.Medscape Public Health
If you need alcohol treatment while practicing physical distancing, there are several professionally led treatment and mutual-support group options available to you:Professionally led treatmentMany healthcare professionals and programs have offered telehealth alcohol treatment for years. These are phone or video sessions for talk therapy or medical care. Now, with the COVID-19 emergency, more providers are offering telehealth services. Medicare and other insurers are expanding coverage of telehealth services as well. Check with your insurance company about coverage.
With all the preparations, it was hoped that Paris would be at the optimistic end of predictions for the COVID-19 epidemic, but as the weeks pass, it looks more and more like a catastrophe is coming.Medscape Medical News
Conclusions.SCIT with house dust mixture of ROXALL Medicina España S.A. seems to have an acceptable tolerability profile, induces blocking IgG and decreases skin reactivity. PMID: 32223886 [PubMed - as supplied by publisher]
Publication date: Available online 1 April 2020Source: Catalysis CommunicationsAuthor(s): Chaoyang Fan, Ruiyi Wang, Peng Kong, Xiaoyu Wang, Jie Wang, Xiaochao Zhang, Zhanfeng Zheng
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ00959H, PaperKai Sheng, baoqian ji, Lei Feng, Yanmin Su, Marko Jagodic, Zvonko Jaglicic, Di Sun The reaction of one equivalent of 1,2-bis-(3,5-dimethylpyrazol-1-yl)-ethane-1,2-diol (H2bdped) with two equivalents of Ni(OAc)2 •4H2O afforded a hexanuclear nickel(II) cluster [Ni6(bdped)2(OAc)8(H2O)4]•6EtOH (SD/Ni6a). The single-crystal X-ray diffraction (SCXRD) structural analysis reveals the one-dimensional... The content of this RSS Feed (c) The Royal Society of Chemistry
Proportion is far higher than those found in clinical trials of the cancer drugs; study finds differences by cancer type.Medscape Medical News
The use of alcohol and other drugs has been identified as a significant factor related to suicide through multiple pathways. This paper highlights current understanding of their contributions to suicide in Canada and identifies opportunities for enhancing ...
BACKGROUND AND OBJECTIVES: There is a well-established causal link between substance use and intimate partner violence (IPV) perpetration and victimization. However, little is known about the complex emerging relationship between cannabis use and IPV. Beca...
Abstract Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective cyclooxygenase inhibitor], nasal polyps, asthma) and additional features, including eosinophilic chronic rhinosinusitis, hypereosinophilia, anosmia, frequent absence of atopy, and, intolerance to ingestion of red wine and other alcoholic beverages. The diagnosis is rare, and, because of this, it is also often missed by physicians. However, it is highly overexpressed in patients with severe asthma (and severe chronic rhinosinusitis with ...