Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat.

Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat. Int J Biol Macromol. 2020 Jan 23;: Authors: Zarei-Kheirabadi M, Sadrosadat H, Mohammadshirazi A, Jaberi R, Sorouri F, Khayyatan F, Kiani S Abstract spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, is a good selection that can increase of viability and differentiation of NSCs. Importantly, we demonstrate that encapsulation of human embryonic stem cell derived-neural stem cells (hESC-NS) in HA-based hydrogel can increased differentiation these cells into oligodendrocytes and improved locomotor function. PMID: 31982534 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research

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Conclusion Consequently, characterization of epidural ASCs, will pave the way for new studies investigating their use in dural and also central nervous system healing and recovery after an injury. PMID: 32222128 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Source: International Journal of Neuroscience - Category: Neuroscience Authors: Source Type: research
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Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
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Stem Cells and Development, Ahead of Print.
Source: Stem Cells and Development - Category: Stem Cells Authors: Source Type: research
Abstract Spinal cord injury (SCI) as a devastating and life-altering neurological disorder is one of the most serious health issues. Currently, the management of acute SCI includes pharmacotherapy and surgical decompression. Both approaches have been assumed to have adverse physiological effects for SCI patients. Therefore, novel therapeutic targets for the management of SCI are urgently required for moving experimental strategies forward cell-based therapies. Multipotent Stem stem cells as a novel strategy for the treatment of tissue injury may provide an effective therapeutic option against many neurological dis...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Spine - Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research
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Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
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Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
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