Lasers and photodynamic therapy in the treatment of onychomycosis: a review of the literature.

Lasers and photodynamic therapy in the treatment of onychomycosis: a review of the literature. Dermatol Online J. 2013;19(9):19611 Authors: Becker C, Bershow A Abstract Onychomycosis is a widespread problem. Oral antifungal medications are currently the gold standard of care, but treatment failure is common and oral therapy is contraindicated in many cases. There is a need for effective treatment without the systemic complications posed by oral therapy. Laser and photodynamic therapy may have the potential to treat onychomycosis locally without adverse systemic effects; some small studies have even reported achieving clinical and mycologic cure. However, there is reason for restraint; these therapies are expensive and time-consuming. Furthermore, they may not be covered by insurance and have not been proven effective with randomized, controlled clinical trials. This paper will review current literature regarding the use of laser and photodynamic therapy as potential treatments for onychomycosis. PMID: 24050286 [PubMed - in process]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research

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Authors: Ishijima SA, Hiruma M, Sekimizu K, Abe S Abstract The prevalence of tinea pedis (also known as athlete's foot) in Japanese workers as well as contamination of their footwear by pathogenic filamentous fungi were investigated. Health checks by a dermatologist at a factory located in the Kanto region (Japan) led to a clinical and morphologic diagnosis of tinea pedis in 9 of 19 workers. Scales obtained from the feet and dust obtained from the protective footwear (safety shoes) worn daily in the factory were obtained from these nine subjects and tested using a mycological culture technique. Scales obtained from...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Conclusion: The multiplex qPCR assays were reliable for the diagnosis of onychomycosis, with shorter turn-around time as compared to culture method. This aids in the planning of treatment strategies to achieve optimal therapeutic outcome. PMID: 31526456 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Condition:   Onychomycosis of Toenail Intervention:   Device: Fungal Nail Treatment Kit Sponsor:   Reckitt Benckiser Healthcare (UK) Limited Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report here the results of the 2016 epidemiological survey of dermatomycosis in Japan. In total, 6,776 cases were analyzed as follows: dermatophytosis, 5,772 cases (85.2%); candidiasis, 757 cases (11.2%); Malassezia infection, 235 cases (3.5%); and other fungal infections, 11 cases (0.2%). In dermatophytosis, tinea pedis was the most frequent (3,314 cases: male, 1,705; female, 1,609), followed by tinea unguium (1,634 cases: male, 766; female, 868), tinea corporis (423 cases: male, 241; female, 182); tinea cruris (316 cases: male, 242; female, 74); tinea manuum (58 cases: male, 29; female, 29); tinea capitus, Celsus' ker...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
Authors: Kawai M Abstract Tinea pedis and tinea unguium are the most common dermatophytoses seen in the daily practice of dermatology. According to a report in Japan Foot Week 2006, it is estimated that about 1 in 5 Japanese have tinea pedis and that about 1 in 10 have tinea unguium. Thus far, use of oral antifungal agents has been the first-line therapy for onychomycosis. Many patients with onychomycosis, however, are elderly and have concomitant diseases as well as liver function disorder. Moreover, oral medications are reportedly associated with risks of impaired liver function and interactions. Due to such risk...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
As growing the number of aging population and immunocompromised patients, there has been an increase in patients with skin fungal infections. Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans are known as the key pathogen of superficial dermatomycosis. Although itraconazole, terbinafine, amorolfine, and ciclopirox have been used for the treatment of these infections, they have limitation due to the drug side effects and lack of efficacy. In 2014, the Food and Drug Administration approved efinaconazole as a novel antifungals particular in onychomycosis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetics and Cell Based Therapy Source Type: research
PMID: 31468505 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
AbstractPurpose of ReviewAs both onychomycosis and HIV/AIDS are frequently encountered, we aimed to make a review of the existent information to this moment, including classification, evaluation and treatment.Recent FindingsThe new description of dermatophytes will surely originate changes in the classification and probably in the therapeutic approach. Also, we must be watchful for the modifications that may develop in this pathology with the newer antirretrovirals which are in constant evolution and could modify the patients ’ response to dermatophytosis.SummaryAt this moment, we know that onychomycosis is very comm...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Onychomycosis is a common disorder that is difficult to cure. It has a prevalence ranging from 2-13% globally, across all age groups. Prevalence is lower in children (0.7%), but athletes are 2.5-fold more likely to develop the disease, with toenail infections 7 times more prevalent than infection of the fingernails. This is a concern for athletes as it can interfere with their performance. The risk of developing onychomycosis is increased by the warm environment of many sports activities, the use of occlusive footwear, the warm, moist environment associated with socks and sweating, shared, close quarters among athletes, an...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Purpose: Onychomatricoma is an uncommon but benign neoplasm of the nail matrix that has been rarely reported in literature and often misdiagnosed. Fewer than 100 cases have been reported, and multiple tumors were initially misdiagnosed and treated as primary onychomycosis. It predominantly affects women (2-16:1) with a peak incidence in the fifth decade with only one pediatric case ever been reported. It is most commonly seen in Caucasians and has a predilection for fingers rather than toes. The classic clinical signs of OM include xanthonychia, nail plate hypertrophy, splinter hemorrhages, transverse overcurvature of the ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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