A bruise-like patch in a 4-year-old girl.

We describe an interesting case of a 4- year-old girl diagnosed with DFSP. She underwent a modified MMS procedure in which she had two short general anesthetics. The advantage of MMS technique in which the full peripheral and deep margin of the specimen was examined. PMID: 24050287 [PubMed - in process]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research

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Tiphany Chrun1,2*, Sandra Lacôte2, Céline Urien1, Charles-Adrien Richard1, Matthias Tenbusch3, Nicolas Aubrey4, Coralie Pulido5, Latifa Lakhdar5, Philippe Marianneau2* and Isabelle Schwartz-Cornil1* 1VIM-INRA-Université Paris-Saclay, Jouy-en-Josas, France2ANSES-Laboratoire de Lyon, Unité Virologie, Lyon, France3Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Medical Immunology Campus Erlangen, FAU Erlangen-Nürnberg, Erlangen, Germany4ISP, INRA, Université de Tours, UMR 1282 Team BioMAP, Nouzilly, F...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was carried out in accordance with the recommendations of the National Animal Care and Use Committee of the University of Buenos Aires (CICUAL). The protocol was approved by the CICUAL. Mice were kept under a 12-h light/dark cycle, with controlled temperature (23 ± 2°C) and humidity (40–60%) and had ad libitum access to food and water. To produce hTDP-43 transgenic lines, as described previously (Igaz et al., 2011), pronucleus of fertilized eggs from C57BL/6J × C3HeJ F1 matings were injected with a vector containing hTDP-43-WT cDNA. Monogenic tetO-TDP-WT12 mice wer...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
In this study, we used a monosynaptic rabies tracing technique to label the whole-brain inputs to specific cell types in the MOp and MOs simultaneously in a same transgenic mouse. First, 150 nl AAV helper mixtures were injected into the ipsilateral MOp (AP:1.54 mm, ML:1.70 mm, DV:-1.50 mm) and MOs (AP:1.54 mm, ML:0.50 mm, DV:-1.35 mm) in Thy1-cre or Vgat-cre mice respectively, mixed with rAAV2/9-Ef1α-DIO-BFP-2a-TVA-WPRE-pA and rAAV2/9-Ef1α-DIO-RG-WPRE-pA as the ratio of 1:2. Three weeks later, 300 nl RV-ΔG-EnVA-EGFP and RV-ΔG-EnVA-Dsred were injected into the two subregions of the MC respectively. O...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
In this study, the immunohistochemistry results demonstrated that DEPDC1 was high-expressed in breast cancer tissues compared with the paired adjacent normal breast tissues, and its tendency at protein level was consistent with mRNA level from TCGA data. Moreover, DEPDC1 mRNA level revealed the strongest association with poor prognosis and development in breast cancer. In vitro assays showed that DEPDC1 overexpression resulted in significant promotion of proliferation by regulating cell cycle in MCF-7 cells, whilst an opposite effect was found in the MDA-MB-231 cells with DEPDC1 deletion. Notably, further investigation ind...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Pulmonary embolism often is thought of as a great mimicker, as it can masquerade as many other diseases. Once a computed tomography scan reveals a main pulmonary artery mass in a patient with chest pain and shortness of breath, most jump quickly to the potential diagnosis of pulmonary embolism. However, not all pulmonary artery masses are clot. Primary pulmonary sarcoma can and does mimic the mimicker. In this issue, Sanders and colleagues eloquently describe and document a case of primary pulmonary artery sarcoma with the diagnosis made at the time of surgery.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
CARDIAC SARCOMA is a rare primary malignant tumor of the heart. In their “E-Challenge,” Mondal et al. report on a patient with near total occlusion of the right ventricle by a cardiac sarcoma who presented to a Baltimore emergency department.1 Their thorough workup elucidated the diagnosis via a computed tomography scan, which promptly lead to surgical palliation to improve the patient's symptomatology. Also in Baltimore, Harvey et al. once wrote in Differential Diagnosis: The Interpretation of Clinical Evidence that, “In making the diagnosis of the cause of illness in an individual case, calculations of ...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
The incidence of primary cardiac tumors is very rare (0.02% of all cardiac tumors), and the majority of them are benign, with myxoma being the most common.1 The most common primary malignant tumor is sarcoma.2,3 Despite its rarity, a cardiac tumor should be an important differential diagnosis when patients present with critical cardiac symptoms, including heart failure, arrhythmia, or emboli.1 Regardless of the histologic nature of cardiac tumors, they can cause obstruction, stenosis, regurgitation, and emboli.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: E-Challenge Source Type: research
Authors: Addesso L, Koenig D, Huq N Abstract Background: Ewing sarcoma, a rare cause of cord compression, is predominantly of osseous origin but can also originate in soft tissues. Soft-tissue manifestations account for
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
Publication date: July 2018Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Volume 30, Issue 4Author(s): Gaurav Singh, Madan Mishra, Amit Gaur, Abhivyakti Tewari, Udita Dewan, Nidhi ParasharAbstractSpindle cell hemangioendothelioma (SCH) was first described in 1986 by Weiss and Enzinger as a vascular neoplasm, characterized by cavernous blood vessels and spindled areas reminiscent of Kaposi’s sarcoma. The head and neck region is rarely involved with extremely rare muscular involvement; this being the first case of intramasseteric SCH.A 30 year old male presented with a 2-year history of a...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
Authors: Liu Y, Jiang H, Xu Q, Zhou H, Li Y Abstract Liposarcoma is the most common type of soft-tissue sarcoma, and predominantly originates from the extremities and retroperitoneal cavity. However, primary endobronchial liposarcoma is extremely rare. The present study reports on the case of a 54-year-old man, a smoker, diagnosed with primary endobronchial atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLS), which was successfully resected via bronchoscopy. Chest computed tomography (CT) revealed a neoplasm in the left main bronchus measuring 12.8×7.8 mm. Bronchoscopy demonstrated multiple r...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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