A case of microscopic polyangiitis with skin manifestations in a seven-year-old girl.
A case of microscopic polyangiitis with skin manifestations in a seven-year-old girl. Dermatol Online J. 2013;19(9):19624 Authors: Yamada Y, Kitagawa C, Kamioka I, Chen KR, Oka M Abstract A case of a 7-year-old girl with microscopic polyangiitis (MPA) with a skin eruption characterized by maculopapular, erythematous and purpuric lesions on the face, elbows, and knees is presented. Anti-neutrophil cytoplasmic autoantibodies (ANCA) with myeloperoxidase specificity (MPO-ANCA) were identified. Chest X-ray and computed tomography scan revealed diffuse infiltrates in both lung fields, suggesting alveolar hemorrhage. Microscopic hematuria was detected but a renal biopsy showed no abnormalities. Histological examination of a skin biopsy from a purpuric papule showed leukocytoclastic vasculitis of the small vessels in the entire dermis. The patient was treated with prednisolone and mizoribine, resulting in an improvement in the skin lesions except for those on the knee. PMID: 24050297 [PubMed - in process]
We would like to thank James R. Smith and colleagues1 for validating our ANCA renal risk score and confirming our results.2 The unmet need in antineutrophil cytoplasmic antibody –associated vasculitis is a robust risk stratification model to reduce recurrent disease damage and mortality. The key goal is to stratify treatment according to clinico-pathologic risk factors and a reliable biomarker panel predicting vasculitis behavior. This would improve renal and patient surv ival. Therefore, we encourage further validations to refine our score and improve its prognostic value.
This review highlights the current state of knowledge about Hashimoto encephalopathy, and progress in the diagnosis and treatment in Hashimoto encephalopathy. Non ‐specific neurological symptoms, laboratory findings and neuroimaging of Hashimoto encephalopathy make its diagnosis an oversight and difficult, whereas antibodies against NH2‐terminal of alpha‐enolase can be useful as a diagnostic biomarker for Hashimoto encephalopathy. AbstractHashimoto encephalopathy (HE) is an autoimmune encephalopathy associated with autoimmune chronic thyroiditis. The clinical entity and nosology of HE have long been debated. Recently...
Date: Wednesday, 09 25, 2019; Speaker: Mark A. Ahlman, MD, , Staff Clinician, Nuclear Medicine Section, , Radiology and Imaging Sciences, CC; Peter C. Grayson, MD, MSc , Tenure-Track Investigator and Head, Vasculitis Translational Research , Program and Associate Director, Fellowship Program, ; Building: Building 10 (Clinical Center); Masur Auditorium; CME Credit; Videocast Event
CONCLUSION: We recommend the establishment of comprehensive and detailed wound care registries to rapidly collect prospective data on the use of HBOT for these problem wounds. There is a strong case for appropriately powered, multi-centre randomized trials to establish the true efficacy and cost-effectiveness of HBOT especially for vasculitis ulcers that have not improved following immunosuppressive therapy. PMID: 31523797 [PubMed - in process]
Semin Neurol 2019; 39: 482-494 DOI: 10.1055/s-0039-1687915Central nervous system (CNS) infections are a frequently underappreciated potential etiology of cerebrovascular disease. Highlighted in this review are a selection of infectious agents that lead to cerebrovascular complications through various mechanisms including multifocal vasculopathy, focal infiltrative vasculitis and vasospasm, and direct vessel wall invasion and thrombus formation. Diagnosis of stroke due to underlying CNS infection requires a high index of clinical suspicion and careful consideration of neuroimaging, serum, and cerebrospinal fluid studies in ...
CONCLUSION: MPO-ANCA-positive AAV was frequently accompanied by airway comorbidities. In addition to fILD, infectious airway comorbidities were closely associated with those clinical phenotypes and outcomes. PMID: 31523048 [PubMed - as supplied by publisher]
We report a case with GPA, which was diagnosed only after new and advancing symptoms belied the original diagnosis of bilateral facial palsy and aortic mural thrombus.
We present the case of a 73-year-old man with IgA vasculitis after administration of acenocoumarol, confirmed by anatomopathological study. He had cutaneous, joint and renal involvement. With the reintroduction of the drug, the clinical manifestations worsened. They were completely resolved with its suspension, without additional maintenance treatment.ResumenSe presenta el caso de un varón de 73 años con vasculitis IgA tras la administración de acenocumarol, confirmada mediante estudio anatomopatológico. El cuadro cursó con afectación cutánea, articular y renal. La clí...
ConclusionLipid levels increased during remission induction among patients with newly diagnosed AAV and those who were PR3 ‐ANCA positive. Disease activity and ANCA type should be considered when assessing lipid profiles to stratify CVD risk in patients with AAV.
For more information go tohttps://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 9/25/2019 12:00:00 PM