Environmental exposure of northern pike to a primary wastewater effluent: Impact on the lipidomic profile and lipid metabolism
Publication date: Available online 25 January 2020Source: Aquatic ToxicologyAuthor(s): Christine Dépatie, Magali Houde, Jonathan VerreaultAbstractLipids play important roles in growth, reproduction, locomotion, and migration of fish. Municipal effluents, which are complex mixtures of biological and chemical compounds including flame retardants, have been shown to alter lipid metabletabolism in environmentally and experimentally exposed fish. Down-regulation of several genes coding for fatty acid metabolism enzymes has previously been reported in male northern pike (Esox lucius) collected in the St. Lawrence River (QC, Canada) downstream of a major primary wastewater treatment plant (WWTP) point of discharge. The main objective of this study was to investigate the effects of exposure to the Montreal’s WWTP effluent on the lipidomic profile (i.e., fatty acids, acylcarnitines, and phospholipids) as well as the transcription of genes related to lipid metabolism in the liver of northern pike collected upstream and downstream of this WWTP effluent. Halogenated flame retardant concentrations were also determined in pike liver and used as markers of exposure to this effluent. Greater concentrations of saturated and monounsaturated lysophosphatidylcholines (LPCs) and lower concentrations of polyunsaturated LPCs were determined in the liver of pike collected downstream of the WWTP compared to those collected upstream. Lower mRNA levels of peroxisome proliferator-activated ...
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Conditions: Cardiovascular Diseases; Sarcopenic Obesity Interventions: Other: High-Protein Mediterranean Diet; Other: Resistance Exercise; Other: Standard Dietary Advice; Other: Standard Cardiac Rehabilitation Exercise Sponsors: Liverpool John Moores University; University of Chester Not yet recruiting
Conditions: Psoriasis; Atherosclerotic Cardiovascular Disease; Obesity; Dyslipidemia; Cardiometabolic Diseases Interventions: Dietary Supplement: Niagen; Other: Placebo Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Recruiting
I was skeptical, but it turns out there is something to be said for a daily fast, preferably one lasting at least 16 hours.
SummaryBackgroundPharmacological treatment options for adolescents with obesity are very limited. Glucagon ‐like‐peptide‐1 (GLP‐1) receptor agonist could be a treatment option for adolescent obesity.ObjectiveTo investigate the effect of exenatide extended release on body mass index (BMI) ‐SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.MethodsSix ‐month, randomized, double‐blinded, parallel, placebo‐controlled clinical trial in patients (n = 44, 10‐18&thin...
(Columbia University Irving Medical Center) A new study suggests that for women, poor sleep could contribute to unhealthy food choices, increasing the risk of obesity and heart disease.
AbstractBackgroundRisk factors for heart disease include arterial hypertension, high cholesterol, tobacco abuse, and obesity. There is a paucity of data regarding role of ethnicity in bariatric surgery (BS) outcomes. The study ’s aim is to determine if ethnicity plays a significant role in BS outcomes, heart age, and cardiovascular risk.MethodsWe conducted a retrospective review of data collected concurrently from patients who underwent BS from 2010 to 2015. We analyzed demographics, comorbidities, heart age, and cardiovascular risk-score at surgery and 12-month follow-up. Ethnicities categorized were Caucasian and A...