Environmental exposure of northern pike to a primary wastewater effluent: Impact on the lipidomic profile and lipid metabolism

Publication date: Available online 25 January 2020Source: Aquatic ToxicologyAuthor(s): Christine Dépatie, Magali Houde, Jonathan VerreaultAbstractLipids play important roles in growth, reproduction, locomotion, and migration of fish. Municipal effluents, which are complex mixtures of biological and chemical compounds including flame retardants, have been shown to alter lipid metabletabolism in environmentally and experimentally exposed fish. Down-regulation of several genes coding for fatty acid metabolism enzymes has previously been reported in male northern pike (Esox lucius) collected in the St. Lawrence River (QC, Canada) downstream of a major primary wastewater treatment plant (WWTP) point of discharge. The main objective of this study was to investigate the effects of exposure to the Montreal’s WWTP effluent on the lipidomic profile (i.e., fatty acids, acylcarnitines, and phospholipids) as well as the transcription of genes related to lipid metabolism in the liver of northern pike collected upstream and downstream of this WWTP effluent. Halogenated flame retardant concentrations were also determined in pike liver and used as markers of exposure to this effluent. Greater concentrations of saturated and monounsaturated lysophosphatidylcholines (LPCs) and lower concentrations of polyunsaturated LPCs were determined in the liver of pike collected downstream of the WWTP compared to those collected upstream. Lower mRNA levels of peroxisome proliferator-activated ...
Source: Aquatic Toxicology - Category: Toxicology Source Type: research

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Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conditions:   Cardiovascular Diseases;   Sarcopenic Obesity Interventions:   Other: High-Protein Mediterranean Diet;   Other: Resistance Exercise;   Other: Standard Dietary Advice;   Other: Standard Cardiac Rehabilitation Exercise Sponsors:   Liverpool John Moores University;   University of Chester Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Psoriasis;   Atherosclerotic Cardiovascular Disease;   Obesity;   Dyslipidemia;   Cardiometabolic Diseases Interventions:   Dietary Supplement: Niagen;   Other: Placebo Sponsor:   National Heart, Lung, and Blood Institute (NHLBI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I was skeptical, but it turns out there is something to be said for a daily fast, preferably one lasting at least 16 hours.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Obesity Weight Diet and Nutrition Food Source Type: news
SummaryBackgroundPharmacological treatment options for adolescents with obesity are very limited. Glucagon ‐like‐peptide‐1 (GLP‐1) receptor agonist could be a treatment option for adolescent obesity.ObjectiveTo investigate the effect of exenatide extended release on body mass index (BMI) ‐SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.MethodsSix ‐month, randomized, double‐blinded, parallel, placebo‐controlled clinical trial in patients (n = 44, 10‐18&thin...
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
(Columbia University Irving Medical Center) A new study suggests that for women, poor sleep could contribute to unhealthy food choices, increasing the risk of obesity and heart disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Obesity Surgery - Category: Surgery Source Type: research
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Source: Obesity Surgery - Category: Surgery Source Type: research
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