Growth differentiation factor 15 (GDF-15) is a novel orexigen in fish

Publication date: Available online 25 January 2020Source: Molecular and Cellular EndocrinologyAuthor(s): Ayelén Melisa Blanco, Juan Ignacio Bertucci, Cristina Velasco, Suraj UnniappanAbstractGrowth differentiation factor 15 (GDF-15), an anti-inflammatory and anti-tumorigenic cytokine, has been emerging as a regulator of appetite and energy homeostasis in mammals. In fish, the physiological role of this peptide remains to be elucidated. This research aimed to determine the possible role of GDF-15 on food intake in goldfish (Carassius auratus). To achieve our objectives, we first obtained a 595 bp gdf-15 cDNA sequence from goldfish tissues, and examined the tissue expression profile of mRNAs encoding both GDF-15 and its receptor (GFRAL). Both mRNAs were detected in several goldfish tissues, including the hypothalamus, foregut and liver (main tissues regulating appetite and energy balance). Food deprivation for 3 and 7 days significantly upregulated gdf-15 mRNAs in the foregut, but downregulated them in the liver. Our in vivo study using diets with varying amounts of carbohydrates, proteins and fats, and our in vitro study exposing goldfish tissues to different macronutrients revealed that gdf-15 mRNAs are importantly modulated by macronutrients. In general terms, we found an increase in gdf-15 mRNA levels in the goldfish foregut and liver in response to all macronutrients tested. Finally, our in vivo assay testing the effects of GDF-15 on appetite levels demonstrated an ...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research

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Publication date: Available online 17 February 2020Source: NeuroImageAuthor(s): Sander Lamballais, Elisabeth J. Vinke, Meike W. Vernooij, M. Arfan Ikram, Ryan L. MuetzelAbstractGyrification of the cerebral cortex changes with aging and relates to development of cognitive function during early life and midlife. Little is known about how gyrification relates to age and cognitive function later in life. We investigated this in 4,397 individuals (mean age: 63.5 years, range: 45.7 to 97.9) from the Rotterdam Study, a population-based cohort. Global and local gyrification were assessed from T1-weighted images. A measure for glob...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 17 February 2020Source: NeurocomputingAuthor(s): Cuili Yang, Xinxin Zhu, Junfei Qiao, Kaizhe NieAbstractAs extension of traditional echo state networks (ESNs), the polynomial echo state networks (PESNs) have been proposed in our previous work (C.L. Yang, J.F. Qiao, H.G. Han, L. Wang, Design of polynomial echo state networks for time series prediction, Neurocomputing 290 (2018) 148-160.) by employing the polynomial function of complete input variable as output weight matrix. In practice, the generalization performance and computational burden of PESNs are perturbed by redundant or irreleva...
Source: Neurocomputing - Category: Neuroscience Source Type: research
: ‘At diabetes‐like concentration, glucose down‐regulates the placental serotonin transport system in a cell‐cycle‐dependent manner,’ by Unal R., Ahmed B.A., Jeffus B.C., Harney J.T., Lyle C.S., Wu Y.‐K., Chambers T.C., Reece E.A. and Kilic F., Journal of Neurochemistry 101(4) 937‐948, 2007 ( The above article, published online on 23rd January 2007 in Wiley Online Library (, has been retracted by agreement between the Journal's Editor in Chief, J örg B. Schulz, and John Wiley&Sons Ltd. The article has been retracted be...
Source: Journal of Neurochemistry - Category: Neuroscience Tags: RETRACTION Source Type: research
Publication date: May 2020Source: Clinica Chimica Acta, Volume 504Author(s): Damian Jacenik, Jakub FichnaAbstractChemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
We present two cases of a left ventricular diverticulum causing cardiac arrhythmia which led to furth er surgical treatment.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
AbstractThe first successful human heart transplantation was reported on 3 December 1967, by Christiaan Barnard in South Africa. Since then this life ‐saving procedure has been performed in over 120 000 patients. A limitation to the performance of this procedure is the availability of donor hearts with as many as 20% of patients dying before a donor's heart is available for transplant. Today, hearts for transplantation are procured from indiv iduals experiencing donation after brain death (DBD). Interestingly, this, however, was not always the case as the first heart transplants occurred after circulatory dea...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractCoarctation is rare in patients over 50 years of age; however, if present, it can be associated with complex intracardiac pathologies and represent a formidable surgical challenge. Herein, we report a single ‐stage approach for surgical repair of coarctation associated with aortic, mitral, and tricuspid valve pathology using an ascending‐to‐descending aortic bypass with posterior pericardial access.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
Publication date: Available online 16 February 2020Source: The Annals of Thoracic SurgeryAuthor(s): Pirooz Eghtesady
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We describe the clinical outcomes of adults who received ECMO in septic shock.MethodsWe retrospectively studied adults supported on veno-arterial or veno-venous modes of ECMO with septic shock at the time of cannulation from 1/1/2009-12/31/2016 at a quaternary medical center in the United States. The primary outcome was rate of survival to hospital discharge and time to survival using Kaplan-Meier survival estimates. We analyzed survival by mode, previous cardiac arrest and timing of cannulation (
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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