Photodynamic therapy mediated by aluminium-phthalocyanine nanoemulsion eliminates primary tumors and pulmonary metastases in a murine 4T1 breast adenocarcinoma model

Publication date: Available online 25 January 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Mosar Corrêa Rodrigues, Lívia Gumieri Vieira, Frederíco Hillesheim Horst, Eduarda Campos de Araújo, Rayane Ganassin, Carolin Merker, Thomas Meyer, Julia Böttner, Tom Venus, João Paulo F. Longo, Sacha Braun Chaves, Mônica Pereira Garcia, Irina Estrela-Lopis, Ricardo Bentes Azevedo, Luis Alexandre MuehlmannAbstractPhotodynamic therapy (PDT) is effective in the treatment of different types of cancer, such as basal cell carcinoma and other superficial cancers. However, improvements in photosensitizer delivery are still needed, and the use of PDT against more deeply located tumors has been the subject of many studies. Thus, the goal of this study was to evaluate the efficacy of a nanoemulsion containing aluminium-phthalocyanine (AlPc-NE) as a mediator of photodynamic therapy (PDT-AlPc-NE) against grafted 4T1 breast adenocarcinoma tumors in mice (BALB/c). Short after the appearance of the tumor, the animals were divided into groups (n = 5) as follows: untreated; only AlPc-NE and treated with PDT-AlPc-NE. The tumor volume was measured with a digital calliper at specific times. The presence of metastasis in the lungs was evaluated by microtomography and histopathological analyses. The results show that the application of PDT-AlPc-NE eradicated the transplanted tumors in all the treated animals, while the animals from control groups presented a robust in...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research