Supersaturated lipid-based drug delivery systems - exploring impact of lipid composition type and drug properties on supersaturability and physical stability.

CONCLUSIONS: In conclusion, the potential for supersaturation in LBDDS, and the risk of precipitation, was found to be highly drug dependent. The apparent degree of supersaturation was considered a major factor impacting the ability to maintain drug supersaturation upon storage. PMID: 31975613 [PubMed - as supplied by publisher]
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

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In this study, we collected raw water from different elements of a local full-scale plant to investigate the fouling characteristics along a two-stage-module NF process. The fouled membranes at different flux decline ratios were autopsied according to scanning electron microscope (SEM), atomic force microscope (AFM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectrometer (XPS), adenosine triphosphate (ATP), contact angle and zeta potential measurements to track the dynamic evolution of organic, inorganic and biological fouling. Statistical approaches, including principal component analysis (PCA), ...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Conclusion: This study supports the psychometric properties of the Norwegian Self-Efficacy for Therapeutic Use of Self questionnaire in assessing self-efficacy in therapeutic encounters. Further research is needed to address the misfit items and the rating scale issue.Significance: Rasch analysis showed that the Norwegian Self-Efficacy for Therapeutic Use of Self questionnaire is promising to be used as a reliable and valid tool. PMID: 32065554 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Conclusion: People who are overweight or obese are motivated to lose weight because of health issues and feeling more comfortable with their body. The opportunities for weight loss lie in creating habits, routines and structuring everyday life activities to facilitate a healthier lifestyle.Significance: The findings indicate that an occupational therapist should be part of weight-loss interventions. PMID: 32065553 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Publication date: March 2020Source: Results in Physics, Volume 16Author(s): Sheng Zou, Hanbin Xiao, Fangping Ye, Zongchen Li, Wenzhi Tang, Feng Zhu, Chentong Chen, Chao ZhuAbstractThe inevitably formed residual stress in the Selective Laser Melting (SLM) process leads to distortion, crack and even delamination of the workpiece. Single laser is commonly applied during SLM processing. However, its productivity is much lower than multiple lasers. In addition, the research of residual stress with multi-laser condition currently is limited in the open documents. In this paper, a three-dimensional (3D) thermo-mechanical model, w...
Source: Results in Physics - Category: Physics Source Type: research
The objective of the study was to assess the diagnostic accuracy of ultrasonography in detecting nodular lesions in patients with subacute thyroiditis. We conducted a longitudinal study involving 710 patients with subacute thyroiditis who underwent ultrasonographic examinations in a single center between 2008 and 2018. These examinations were performed at initial diagnosis and during follow-up, with subsequent evaluation of nodules using fine needle aspiration cytology. Ultrasonographic examination used for the initial screening of thyroid nodules in patients with subacute thyroiditis showed a sensitivity of 72.4%, specifi...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
In this study, a targeted photothermal delivery nanoplatform (P-D-CS-CNTs) was facilely fabricated by decoration of an acidity-labile polyethylene glycol (PEG) derivative onto chitosan nanoparticles encapsulating single-walled carbon nanotubes. P-D-CS-CNTs displayed a good stability in serum at normal physiological pH and convertibility of surface charges upon exposure to tumoral acidic pH, which was attributed to the acidity-triggered dePEGylation. The confocal laser scanning microscopic observations suggested that such surface-convertibility of nanoparticles facilitated tumor cell uptake, endo/lyososomal escape, and enha...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: May 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 189Author(s): M. Saleem Khan, Chunguang Yang, Ying Zhao, Haobo Pan, Jinlong Zhao, M. Babar Shahzad, Sharafadeen Kunle Kolawole, Ihsan Ullah, Ke YangAbstractThe corrosion behaviour of X80 pipeline steel was studied in a simulated marine environment inoculated with marine bacterium Marinobacter salsuginis. The electrochemical results showed that the increase in linear polarization resistance, charge transfer resistance, and the decrease in corrosion current density of the X80 pipeline steel immersed in the biotic medium indicated its high corros...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: May 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 189Author(s): Iván Rodríguez Durán, Stéphanie Vanslambrouck, Pascale Chevallier, Corinne A. Hoesli, Gaétan LarocheAbstractThe use of polylactic acid (PLA) has attracted growing interest, particularly in recent years, for biomedical applications because of its mechanical properties, biocompatibility, and biodegradability. Despite this, features such as surface hydrophobicity and the absence of suitable functional groups for covalent immobilization of bioactive molecules, make it challenging to endow PLA-based ...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 18 February 2020Source: PolymerAuthor(s): Haiwei Yang, Zongqian Wang, Mingrong Wang, Changlong LiAbstractSilk fibroin aerogel generally suffers from weak mechanical properties, which limits its application in the high-performance materials. Hence, we develop a non-alkali urea degumming strategy for the raw silk to impove the mechanical properties of silk fibroin aerogel. The silk fibroin aerogel with a low density of 13.43 ± 0.77 mg/cm3 was fabricated successfully via silk fibroin dissolution, dilution and freeze-drying. We systematically analyze the solution properties of silk fib...
Source: Polymer - Category: Chemistry Source Type: research
Publication date: 25 June 2020Source: Journal of Alloys and Compounds, Volume 827Author(s): Irfan Ullah, Akhtar Munir, Shoaib Muhammad, Saqib Ali, Nasir Khalid, Muhammad Zubair, Muhammad Sirajuddin, Syed Zajif Hussain, Sajjad Ahmed, Yaqoob Khan, Irshad Hussain, Ali HaiderAbstractBand gap tuning of nanomaterials is a current field of interest in order to transform UV-light active catalysts into visible light driven catalysts. Tungsten-doped SnO2 (W@SnO2) nanospheres (NS) with dopant concentration ranging from 0 to 6 mol%, were prepared and characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
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