A positive approach: advances in proton therapy for the treatment of mediastinal lymphoma.

A positive approach: advances in proton therapy for the treatment of mediastinal lymphoma. Expert Rev Hematol. 2020 Jan 24;: Authors: Mailhot Vega RB, Hoppe BS PMID: 31976780 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research

Related Links:

To investigate the role of intensity modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT) for advanced supradiaphragmatic Hodgkin ’s lymphoma (HL) in young female patients by asse...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
AbstractRadiation therapy represents an important approach in the therapeutic management of children and adolescents with malignant tumors and its application with modern techniques – including Proton Beam Therapy (PBT) – is of great interest. In particular, potential radiation-induced injuries and secondary malignancies – also associated to the prolonged life expectancy of patients – are still questions of concern that increase the debate on the usefulness of PBT in pe diatric treatments. This paper presents a literary review of current applications of PBT in non-Central Nervous System pediatric tu...
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
ConclusionsStudies uniformly show a linear radiation dose-response relationship between mean absorbed dose to the heart (heart-Dmean) and the risk of dying as a result of cardiac disease, particularly when heart-Dmean exceeds 5 Gy. Limited data are available regarding dose-volume predictors for heart substructures and the risk of subsequent cardiac toxicity. An individual patient’s cardiotoxicity risk can be modified with advanced treatment planning techniques, including deep inspiration breath hold. Proton therapy is currently showing advantages in improving treatment planning parameters when compared to advanc...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 2 October 2019Source: Practical Radiation OncologyAuthor(s): Bradford S. Hoppe, James E. Bates, Nancy P. Mendenhall, Christopher G. Morris, Debbie Louis, Meng Wei Ho, Richard Hoppe, Marwan Shaikh, Zuofeng L, Stella FlampouriAbstractBackground &PurposeMean heart dose (MHD) correlates with late cardiac toxicity among survivors of lymphoma receiving involved-field radiotherapy (IFRT). We investigated MHD and cardiac substructure dose across older and newer radiation fields and techniques to understand the value of evaluating MHD alone.Patients &MethodsFollowing IRB approval, we devel...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
The risk-adapted combination of brief chemotherapy followed by radiation therapy (RT), nowadays represents the therapeutic golden standard for early stage Hodgkin lymphoma (HL) [1]. Nonetheless, the role of radiation is still debated, with some concerns for late toxicity (second malignancies, heart disease). Current RT protocols combine limited radiation volumes (involved site or involved nodal radiotherapy, ISRT/INRT) with advanced planning and delivery techniques, such as intensity modulated RT (IMRT), tomotherapy and proton therapy.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Publication date: Available online 22 May 2019Source: Practical Radiation OncologyAuthor(s): Ashlyn S. Everett, Bradford S. Hoppe, Debbie Louis, Andrew M. McDonald, Christopher M. Morris, Nancy P. Mendenhall, Zuofeng Li, Stella FlampouriAbstractIntroductionPatients with lower mediastinal lymphoma (LML) benefit dosimetrically from proton therapy (PT) compared with intensity-modulated radiotherapy (IMRT). The added dosimetric benefit of deep-inspiration breath-hold (DIBH) is unknown; therefore, we evaluated IMRT versus PT and free-breathing (FB) versus DIBH among patients with LML.Materials and MethodsTwenty-one patients wit...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Source: Blood - Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
ConclusionsPBS gives good target coverage and local control while providing reductions in radiation dose to OARs for individuals who receive RT for HL compared with advanced photon RT. Our findings highlight groups of patients who would be expected to gain more dosimetric benefit from PBS. These findings facilitate the selection of patients who should be considered a priority for PT.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
More News: Hematology | Lymphoma | Proton Therapy