nCEREBROLYSIN PREVENTS SLEEP DEPRIVATION INDUCED MEMORY IMPAIRMENT AND OXIDATIVE STRESS

In this study, the effect of CBL on sleep-deprivation induced memory impairment was investigated. Sleep deprivation was induced in rats using the modified multiple platform model (8 hours/day for 4 weeks). Concurrently, CBL was administered intraperitoneally for four weeks. Animal's performance (spatial learning and memory) was assessed using the radial arm water maze (RAWM). Additionally, oxidative stress biomarkers including reduced glutathione (GSH), oxidized Glutathione (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), and catalase were assessed in the hippocampus. Current results showed that sleep deprivation impaired both short- and long- term memories (P
Source: Physiology and Behavior - Category: Physiology Source Type: research

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This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
In this study, the effect of CBL on sleep-deprivation induced memory impairment was investigated. Sleep deprivation was induced in rats using the modified multiple platform model (8 h/day for 4 weeks). Concurrently, CBL was administered intraperitoneally for four weeks. Animal's performance (spatial learning and memory) was assessed using the radial arm water maze (RAWM). Additionally, oxidative stress biomarkers including reduced glutathione (GSH), oxidized Glutathione (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPx), and catalase were assessed in the hippocampus. Current results showed that sleep deprivation imp...
Source: Physiology and Behavior - Category: Physiology Source Type: research
WEDNESDAY, Jan. 29, 2020 -- Suvorexant improves total sleep time (TST) in patients with probable Alzheimer disease (AD) dementia and insomnia, according to a study published online Jan. 15 in Alzheimer's&Dementia. W. Joseph Herring, M.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Herring WJ, Ceesay P, Snyder E, Bliwise D, Budd K, Hutzelmann J, Stevens J, Lines C, Michelson D Abstract INTRODUCTION: We evaluated the clinical profile of the orexin receptor antagonist suvorexant for treating insomnia in patients with mild-to-moderate probable Alzheimer's disease (AD) dementia. METHODS: Randomized, double-blind, 4-week trial of suvorexant 10 mg (could be increased to 20 mg based on clinical response) or placebo in patients who met clinical diagnostic criteria for both probable AD dementia and insomnia. Sleep was assessed by overnight polysomnography in a sleep laboratory. The primar...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Sleep disturbances such as insomnia are extremely common, especially in women after menopause. According to data from the National Institutes of Health, sleep disturbance varies from 16% to 42% before menopause, from 39% to 47% during perimenopause, and from 35% to 60% after menopause. Insomnia is a serious medical problem defined by frequent difficulty falling or staying asleep that impacts a person’s life in a negative way. Hormone changes around menopause can lead to sleep problems for many reasons, including changing sleep requirements, increased irritability, and hot flashes. What menopausal women eat could have...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Fatigue Food as medicine Healthy Eating Menopause Nutrition Sleep Source Type: blogs
We present a case of a 72-year-old male with anti-DPPX encephalitis who developed rapidly progressive cognitive decline, psychiatric and sleep problems, severe abdominal pain and diarrhea. Antibodies against DPPX were positive both in serum and cerebrospinal fluid. 18F-FDG PET-MR imaging indicated hypometabolism in the bilateral temporal lobes and thalamus. No related tumors were found, and the patient responded to immunotherapy without relapse at the 3-year follow-up.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: Short Communication Source Type: research
ConclusionsA history of MST is common among older women veterans and associated with a range of medical and mental health diagnoses. These findings call attention to the need for additional research in this understudied population, and the importance of trauma-informed care approaches for women across the lifespan.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Conditions:   Dementia;   Alzheimer Disease;   Circadian Rhythm Disorders;   Circadian Rhythm Sleep Disorder;   Insomnia;   Hypersomnia;   Cognitive Impairment;   Cognitive Decline;   Mild Cognitive Impairment;   Frontotemporal Dementia;   Neurocognitive Disorders;   Vascular Dementia;   Sleep Disorder;   Memory Impairment Intervention:   Behavioral: Tailored music listening intervention Sponsor:   University of Pennsylvania Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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