Target-Enriched Next-Generation Sequencing Reveals Differences between Primary and Secondary Ovarian Tumors in Formalin-Fixed, Paraffin-Embedded Tissue
Differentiating primary endometrioid or mucinous ovarian tumors from secondary ovarian tumors can be challenging. We compared somatic mutation profiles of primary and secondary ovarian cancers to investigate if these profiles can help diagnose ovarian tumors. Cancer-related genes (n = 115) were screened by target-enriched next-generation sequencing in formalin-fixed, paraffin-embedded tumor tissue from 43 primary endometrioid and mucinous ovarian carcinomas and 28 proven colorectal cancer metastases to the ovary.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Stijn Crobach, Dina Ruano, Ronald van Eijk, Gert Jan Fleuren, Ivonne Minderhout, Ronelle Snowdowne, Carli Tops, Tom van Wezel, Hans Morreau Tags: Regular Article Source Type: research
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