Examining the Functional Activity of Different Obsessive-Compulsive Symptom Dimensions in Tourette Syndrome

Conclusion: Our findings implicate areas previously reported to be involved in OCD, as well as areas not typically implicated in OCD, suggesting that the neurobiological profile of TS+OCD is intermediate to pure TS and pure OCD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Publication date: Available online 30 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Tracy Bhikram, Paul Arnold, Adrian Crawley, Elia Abi-Jaoude, Paul SandorAbstractTourette Syndrome (TS) is characterized by the presence of tics and sensory phenomena, such as premonitory urges, and is often accompanied by significant obsessive-compulsive symptoms (OCS). The goal of this exploratory study was to determine the association between functional connectivity and the different symptom domains of TS, as little is currently known about how they differ. Resting-state functional magnetic resonance imaging was performed ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
IntroductionAlthough defined by the presence of tics, most patients with Gilles de la Tourette syndrome (TS) also suffer from different psychiatric disorders. While much is known about clinical characteristics of comorbidities such as attention deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), depression, and anxiety disorders, only very little is known about rage attacks. Most of this data is based on small studies in children. Until today no larger studies have been performed in adults with TS—most likely because of the lack of validated instruments. The aim of this study was to develop a ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionThe high beta and gamma oscillations in GPi restored after GPi ‐DBS, but not STN‐DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN‐DBS due to the influence on the hyper‐direct pathway but not GPi‐DBS.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Obsessive-compulsive spectrum disorders (OCSD), including OCD, body dysmorphic disorder (BDD), body-focused repetitive behaviors (BFRBs, such as trichotillomania and skin-picking disorder), and chronic tic disorders/Tourette ’s disorder (TD) share overlapping clinical phenomenology and associated dysregulated subcortical neurocircuitry. The cortico-striatal-thalamo-cortical (CSTC) neural pathway is involved in the regulation of behaviors (cognitive and emotional), and as such, disruption can result in a variety of und esired, repetitive manifestations (ie, tics, obsessions/compulsions, picking/pulling).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Clinical Perspectives 51 Source Type: research
Becker muscular dystrophy (BMD) results in a decrease of dystrophin with potential implications for cognitive and psychiatric complications. To better understand these concerns, we conducted a retrospective study of the neuropsychological symptoms and respective pharmacotherapies of 74 BMD patients. Eight (10.8%) patients exhibited autistic features, 26 (35.1%) exhibited inattention/hyperactivity, 23 (31.1%) had learning difficulties, 27 (36.5%) had language delays, 9 (12.2%) had global intellectual delays, 4 (5.4%) had features of tics or Tourette's, 27 (36.5%) had emotion dysregulation, 14 (18.9%) had obsessive-compulsiv...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
We examined 165 consecutive GTS patients aged 5–50 years old (75.8% males). The patients were evaluated for GTS and co-morbid mental disorders according to the DSM-IV-TR. SHB was diagnosed during the interview. To determine a direct relationship between SHB and clinical variables, we conducted two analyses, at the time of evaluation and lifetime. We also compared the group of children and adults with SHB and tried to distinguish between deliberate (non-tic related SHB) and accidental (tic related SHB). Lifetime SHB was reported by 65 patients (39.4%). In 30 of the patients (46.2%), SHB was evaluated as mild, in 26 (4...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
This study suggests that there is no difference in aggressive behavior between children with tics without comorbidities and healthy children. It is possible that aggressive behavior in children with tic disorders is predominantly associated with comorbid attention-deficit hyperactivity disorder.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
PURPOSE OF REVIEW The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options. It is hoped that a greater understanding of each of these components will provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals. RECENT FINDINGS Recent advances include the finding that Tourette syndrome is likely due to a combination of several different genes, both low-effect and larger-effect variants, plus environmental factors. Pathophysiologically, increasing e...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
Conclusions: Both typical and atypical antipsychotic agents are mainstays of pharmacological treatment of TS and other chronic tic disorder patients; however, their use is limited by serious side effects considering their potential of dopamine blockade. Because of the phenotypic variability, no medication has proven effective for all persons with TS and other chronic tic disorders. Botulinum toxin has emerged as a good therapeutic option, especially for focal and dystonic tics. But, their uses are limited by lack of sufficient evidence and high cost. Surgical treatment is considered in medically refractory and severely d...
Source: The Neurologist - Category: Neurology Tags: Review Article Source Type: research
In conclusion, our study demonstrates that TS patients manifest “trait” abnormalities in the timing of sequential motor tasks, which are in keeping with the continuation phase of time processing, likely controlled by the sensorimotor loop of the cortico-basal ganglia network. We also show that the abnormal lateralization of fine motor control, previously reported in the context of the structural sequencing of fine motor tasks, extends also to motor timing accuracy. Finally, we highlight SMA connectivity as a potentially pivotal neural substrate of adaptive compensation of motor timing deficits in fine manual ta...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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