A registered report of error-related negativity and reward positivity as biomarkers of depression: P-Curving the evidence

Publication date: Available online 24 January 2020Source: International Journal of PsychophysiologyAuthor(s): Peter E. Clayson, Kaylie A. Carbine, Michael J. LarsonAbstractPerformance-monitoring event-related brain potentials (ERPs), such as the error-related negativity (ERN) and reward positivity (RewP), are advocated as biomarkers of depression symptoms and risk. However, a recent meta-analysis indicated effect size heterogeneity in the ERN and RewP literatures. Hence, advocating these ERPs as biomarkers of depression might be premature or possibly misguided due to the selective reporting of significant analyses on the part of researchers (e.g., p-hacking or omission of non-significant findings). The present study quantified the degree of selective reporting and the evidential value for a true relationship between depression and ERN and RewP using a p-curve analysis. We predicted that the ERN and RewP literatures would fail to show evidential value for a relationship between each ERP and depression. Contrary to expectations, both literatures showed evidential value, albeit weak. The statistical power of the included ERN studies was between 20% and 25%, and the statistical power of the RewP was around 27%. Taken together, these findings provide support for a relationship between these ERPs and depression, which strengthens claims that these ERPs represent candidate biomarkers of depression symptoms and risk. In light of the evidence for these relationships being weak, some r...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research

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Publication date: April 2020Source: Fish &Shellfish Immunology, Volume 99Author(s): Zhichu Chen, Diana Ceballos-Francisco, Francisco A. Guardiola, M. Ángeles EstebanAbstractThe effects of skin wounds on the intestinal barrier function and the beneficial effects of the dietary administration of Shewanella putrefaciens (known as SpPdp11) in gilthead seabream (Sparus aurata L.) were studied. Two replicates of fish were fed a commercial diet (control, CON) or CON diet enriched with 109 cfu g−1 SpPdp11 (SP diet) for 30 days. After this time, half of the fish were sampled, while the others were injured...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Authors: Shiroma PR, Velasquez T, Usset TJ, Wilhelm JH, Thuras P, Baltutis E Abstract INTRODUCTION: Obesity is prevalent among users of Veteran's Health Administration services, where it is comorbid with depression, post-traumatic stress disorder, type 2 diabetes, cardiovascular disease, colon, and breast cancer. Among obese subjects, severe obesity represents a subpopulation with the highest risk of depression. We investigate the antidepressant effect of a local VA weight management program (Managing Overweight Veterans Everywhere - MOVE) among depressed veterans with severe obesity. MATERIAL AND METHODS: In a...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
CONCLUSION: Findings suggest few soldiers-in-training are likely to seek help when experiencing a problem. General efforts to encourage help-seeking when needed are warranted with particular focus on subsets of soldiers-in-training (eg, men, those with a history of some adverse childhood experiences). Strengths of this study include the examination of a large sample of soldiers-in-training to identify possible leverage points for early intervention or prevention prior to entering stressful military operating environments. Limitations of this study include the examination of only one military branch and exclusion of soldier...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
This study examined treatment-related changes in depression, anger, and PTSD following cognitive processing therapy (CPT) as potential predictors of QOL change. MATERIALS AND METHODS: Data from two randomized controlled trials, one examining CPT among female civilians and veterans (women's study NCT02362477; n = 126) and the other on CPT delivered to male veterans (men's study NCT00879255; n = 125), were used to test study aims. Linear mixed modeling examined changes in depression, anger, and PTSD as predictors of post-treatment QOL while controlling for baseline QOL. The VA Pacific Island Health Ca...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
The objective of our work was to evaluate if the breakage of a dam containing wastefrom a mining cite in Brazil, in 2015, an environmental disaster popularly known as the Mariana Tragedy, affected the health of newborns exposed in utero. We used administrative data on birth records and reports on the Mariana Tragedy to identify all births from newborns exposed in utero and the intensity of that exposure, according to the mother's municipality of residence. Using a difference-in-differences framework, we estimated the impact of different intensities of exposure on birth outcomes. We found that being directly exposed in uter...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
ConclusionsOur study demonstrates a differential association between ACEs and anxiety and depression. Thus, highlighting the importance of assessing the impact of ACEs on internalizing behaviors separately. These findings are significant for pediatric providers as diagnosis and treatment for mental health disorders are a vital component of pediatric care and further supports the American Academy of Pediatrics recommendation to screen for ACEs.
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
CONCLUSIONS: The results suggest a strong need for neuropsychological assessments and evidence-based cognitive rehabilitation strategies to be implemented immediately after TBI in Latin America, which could exert salubrious effects on depression trajectories over time. PMID: 32083603 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
CONCLUSION: Given the abrupt and significant life-changing nature of stroke, it is often necessary to manage a diverse array of psychological issues that often cannot be simply managed via psychotropic medications. Moreover, an understanding of the patients' emotional adjustment and issues can help them maximize their rehabilitation, recovery, and community integration. For the cases discussed, psychology consultations were central in helping optimize their rehabilitation and functional outcomes. PMID: 32083601 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
CONCLUSIONS: Persistent Sport-Related Post-Concussion Syndrome is a topic of great interest to both professionals and the general public. There is much misunderstanding about the etiology, causation, diagnostic formulations, symptom presentation, prolonging factors and treatment involved in this syndrome. This article posits an individualized multi-system diagnostic formulation, examining all relevant factors, as generating the best interventions for neurorehabilitation of Persistent Sport-Related Post-Concussion Syndrome. PMID: 32083597 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
In conclusion, association analysis is useful to extract core knowledge. Researchers can learn and visualize the latest research trend. PMID: 32076454 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
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