Ocular blood flow as a clinical observation: value, limitations and data analysis

This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while laying a path for integrating clinical observations with mathematical models and artificial intelligence. Viable alternatives for integrated data analysis are proposed that aim to overcome the limitations of standard statistical approaches and enable individually tailored precision medicine in ophthalmology.
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research

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Abstract PURPOSE: Several risk factors have been identified for central retinal vein occlusion (CRVO) in older population. CRVO in young is uncommon, and the risk factors for this group are unclear. This large retrospective, cross-sectional study used the National Inpatient Sample (NIS) database to evaluate the risk factors for CRVO in patients 18 to 40 years of age. METHODS: The 2002 to 2014 NIS database was used. All patients 18 to 40 years of age with a primary diagnosis of CRVO were identified. Age- and gender-matched non-CRVO controls were randomly selected. The primary outcome was identifi...
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Conclusions: No significant differences were found in peripapillary and macular microcirculation detected by OCTA between AD and ED glaucomatous eyes. Peripapillary and macular microcirculation were significantly correlated with disease severity in AD and ED glaucomatous eyes.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
With the summer winding down and fall moving in, colder weather will arrive soon — along with cold and flu season. Millions of Americans get the common cold each year, often more than once. To counter coughs and runny noses, many will turn to over-the-counter (OTC) medications available for relief without a prescription. Heading to the pharmacy for some relief? Read this first While OTC medicines do not cure or shorten the common cold or flu, they can ease some symptoms. Finding a product that fits your needs, however, may not be so straightforward. A recent study evaluated brand-name OTC medications marketed as cold...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cold and Flu Drugs and Supplements Health Infectious diseases Source Type: blogs
Glaucoma remains the world’s leading cause of irreversible blindness and though intraocular pressure (IOP) is the most prevalent risk factor and only reliable therapeutic target, a number of systemic disease associations have been reported. Metabolic syndrome (MetS) is a constellation of findings that includes systemic hypertension, abdominal obesity, glucose intolerance, and dyslipidemia. MetS is becoming increasingly common worldwide, with prevalence up to 40% in some countries. Not only is MetS a significant cause of morbidity, but it is also associated with an increase in all-cause mortality. Reports have been co...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Review Articles Source Type: research
CONCLUSION: Macular segmentation can assist in the early diagnosis of glaucoma as a complementary study to pRNFL analysis. PMID: 32839014 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Both retrobulbar hemorrhage and plate extrusion are uncommon complications after implantation of a glaucoma drainage device (GDD). There are no published reports on extrusion of an Ahmed glaucoma valve after delayed-onset retrobulbar hemorrhage in Korea. Herein, we report a case of spontaneous extrusion of a GDD after delayed-onset retrobulbar hemorrhage in a patient on anticoagulation. The case was a 72-year-old man with open-angle glaucoma and proliferative diabetic retinopathy, as well as systemic hypertension, atrial fibrillation, congestive heart failure due to coronary heart disease, and chronic kidney disease, who u...
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
CONCLUSION: Nearly one-third of the sample were estimated to have lens opacities, or had undergone cataract surgery, making cataract a frequent disorder of older age. The study provided further evidence that increasing age, female gender, and myopia are associated with cataract. PMID: 32757792 [PubMed - as supplied by publisher]
Source: Upsala Journal of Medical Sciences - Category: General Medicine Authors: Tags: Ups J Med Sci Source Type: research
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Abstract AIMS: To determine the association between albuminuria and primary open-angle glaucoma (POAG). METHODS: Participants of the Singapore Chinese Eye study were recruited and underwent standardised ocular and systemic examinations. Albuminuria was determined using urinary albumin-to-creatinine ratio (UACR, mg/g) based on random spot urinary albumin and creatinine measurements. POAG was defined using the International Society of Geographic and Epidemiological Ophthalmology classification. Multivariable logistic regression with generalised estimating equation model was used to evaluate the association betw...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Conclusions: Significant alterations in serum levels of apelin and ADMA may suggest potential effects in vascular pathologies and a possible role in predisposition to vascular comorbidities in XFS/XFG.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
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