Ocular blood flow as a clinical observation: value, limitations and data analysis

This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while laying a path for integrating clinical observations with mathematical models and artificial intelligence. Viable alternatives for integrated data analysis are proposed that aim to overcome the limitations of standard statistical approaches and enable individually tailored precision medicine in ophthalmology.
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research

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AbstractGlaucoma is a leading cause of bilateral blindness. Phosphodiesterase type 5 inhibitors (PDE5Is; e.g. avanafil, sildenafil, tadalafil and vardenafil) may increase blood flow to the ciliary body, thereby elevating intraocular pressure and increasing the risk of glaucoma. PDE5Is are commonly used to treat erectile dysfunction, as well as benign prostatic hyperplasia (tadalafil) and pulmonary hypertension (sildenafil). Patients receiving PDE5Is require glaucoma education and ongoing screening, especially if they are taking a high dosage of a daily PDE5I or have risk factors for glaucoma (e.g. increased age, African-Am...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Authors: Kalala A, Gillmann K, Mermoud A Abstract PURPOSE: Two of the hurdles that are facing ophthalmologists in developing countries are scarcity of resources and patient follow-up. Deep sclerectomy (DS) has proven less costly and more effective than topical therapies and has a more favorable safety profile than trabeculectomy. The main factors preventing its use in developing countries are the need to perform laser goniopuncture in 40-80% of cases to maintain filtration and the risk of postoperative iris incarceration. The purpose of this study is to assess the efficacy and safety profile in advanced open-angle ...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
(AEEC) Abstract AIM: To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies. METHODS: 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. Chroni...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Conclusion: People with T2DM presenting at eye clinics in India have high rates of diabetic retinopathy and vision loss. Cataract is a very common occurrence. Advocacy, infrastructure strengthening, and human resource development are the key to address the growing threats of T2DM and eye care in India.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract The purpose of this study was to determine if there is an association between tinnitus and glaucoma. We tested this by first completing a clinic-based cross-sectional questionnaire study in which we sent a series of tinnitus-related questions to glaucoma patients and healthy subjects, and then followed up with a large population-based cross-sectional study in which glaucoma and tinnitus were also assessed by questionnaire. For the clinical study, we received 209 responses from glaucoma patients and 109 responses from healthy subjects (primarily the spouses of the patients). For the population-based study,...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Most cough/cold preparations contain sympathomimetic decongestants; many contain sedating antihistamines. Adverse effects, including death in children under 2, primarily from decongestants, but also from sedating antihistamines and dextromethorphan prompted FDA to recommend OTC cough and cold products not be used in this group. This, combined with manufacturer withdrawal under age 4, has created a cough and cold market void for young children in the US. Also, decongestant adverse effects in adults, including increased blood pressure, irregular heartbeat, and chest tightness resulted in contraindication in heart disease, hi...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conditions:   Retinitis Pigmentosa;   Maculopathy, Age Related;   Macular Dystrophy;   Macular Edema;   Retinal Detachment;   Retinal Degeneration;   Glaucoma;   Vascular Inflammation;   Hypertension;   Stroke;   Diabetes;   Corneal Dystrophy;   Keratoconus;   Dry Eye;   Trauma Interventions:   Device: High-resolution retinal imaging through adaptive optics;   Device: High-resolution retinal imaging through holographic systems Sponsor:   Centre Hospitalier National d'Ophtalmologie des ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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