Depressive-like phenotype evoked by lifelong nutritional omega-3 deficiency in female rats: crosstalk among kynurenine, Toll-like receptors and amyloid beta oligomers

Publication date: Available online 24 January 2020Source: Brain, Behavior, and ImmunityAuthor(s): Maria Grazia Morgese, Stefania Schiavone, Angela Bruna Maffione, Paolo Tucci, Luigia TrabaceAbstractDepression is one of the most common psychiatric diseases and the prevalence of depressive symptoms in women is almost twice compared to men, although the reasons of this gender difference are not fully understood yet. Recently, soluble amyloid beta (Aβ)1-42 peptide has been receiving great importance in the development of depression, also considering that depression is highly comorbid with Alzheimer’s disease and other neurodegenerative illnesses. The central role played by Aβ in the development of depressive-like symptoms in rodents has been evidenced in environmental rodent model of depression. Indeed, we have previously found that lifelong exposure to n-3 polyunsaturated fatty acids (PUFA) deficient diet in female rats at 8 weeks of life leads to depressive like- symptoms and higher susceptibility to stress associated with increased Aβ levels. In order to understand if such effects were maintained over time, rats were exposed to the same diet regimen until 6 or 21 weeks of life. We found that both timepoints of exposure to n-3 PUFA deficient diet lead to depressive-like phenotype. Furthermore, a significant alteration in brain neurochemistry was retrieved. In particular, in hippocampal area a significant reduction in serotonin (5-HT) and noradrenaline (NA) ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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This study aims to extract changes in the gray matter of these patients and test how these changes account for the PSD symptoms. High-resolution T1 weighted images were collected from 23 PSD patients diagnosed with subcortical stroke. Voxel-based morphometry and support vector machine analyses were used to analyze the data. The results were compared with those collected from 33 non-PSD patients. PSD group showed decreased gray matter volume (GMV) in the left middle frontal gyrus (MFG) when compared to the non-PSD patients. Together with the clinical and demographic variables, the MFG's GMV predictive model was able to dist...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusions: We confirm the relevance of developing multidisciplinary caregiver intervention programmes focused on positive ways to handle care-recipients' behavioral problems and developing positive coping skills, such as positive reinterpretation, acceptance and seeking social support, that may optimize caregiver resilience. PMID: 32073318 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
This study aimed to elucidate any connection between central sensitization and ongoing pain after knee replacement surgery and other associated factors. Methods: The population was composed of 182 patients who had undergone TKR, and in follow-up visits from 1 mo to 2 yr after the operation, they were evaluated using the Pressure Pain Threshold (PPTs), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Central Sensitization Inventory (CSI), the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), the Beck Depression Inventory (BDI), and the painDETECT test. Results: Th...
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
According to this study: Shift workers, especially women, are at increased risk for poor mental health, particularly regarding symptoms of depression.
Source: AJN - Category: Nursing Tags: Journal Watch Source Type: research
Conclusions: Our results indicate that, in addition to previously identified predictors of inadequate physical activity in cancer survivors, having arthritis-related functional limitations is a significant predictor of inadequate physical activity in female adult cancer survivors. Assessment and management of arthritis-related functional limitations by health care providers are needed to facilitate successful adherence to physical activity guidelines.
Source: AJN - Category: Nursing Tags: Original Research Source Type: research
Recently, Lin et  al1 suggested that high-flow nasal cannula oxygen therapy was superior to 2 L/min by nasal cannula in terms of the incidence of hypoxia and severe hypoxia among America Society of Anesthesiologists class I–II patients undergoing elective gastroscopy with low-dose propofol sedation (mean dose, 10 6 mg). Hypoxia and severe hypoxia occurred in 8.4% of patients with nasal 2 L/min cannula oxygen therapy versus 0.6% of patients with high-flow oxygen. This differs markedly from our experience with low-dose propofol sedation for diagnostic EGD done without routine supplemental oxygen.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Poor treatment for those who self-harm or attempt suicide is putting lives at risk, psychiatrists say.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Publication date: Available online 20 February 2020Source: Materials Chemistry and PhysicsAuthor(s): Bashir Mosayyebi, Mahsa Imani, Leila Mohammadi, Abolfazl Akbarzadeh, Nosratollah Zarghami, Mahdi Edalati, Effat Alizadeh, Mohammad RahmatiAbstractCyanogenic glycosides are defined as natural herbal toxins which are found in more than 2000 plant species and most of them consumed by humans. These nitrile-containing compounds do not present toxic effects in intact form while they produce toxic cyanide following enzymatic digestion. Therefore, over-consuming of these compounds can lead to cyanide poisoning. On the other hand, s...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
This study aimed to assess the feasibility/utility of using the ARCS in the assessment of depressed patients undergoing ECT. Methods Depressed patients undergoing ECT were tested with the ARCS and a comparison instrument, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), in counterbalance order immediately before any ECT and after the sixth ECT treatment episode. Apathy (Apathy Scale) and depression (Profile of Mood states Short Form) were measured on both occasions. Analyses compared performances on the 2 cognitive instruments and examined for associations with the measures of apathy or de...
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research
Objectives It remains controversial whether a subanesthetic dose of ketamine could modulate the antidepressant effect of electroconvulsive therapy (ECT) in patients with major depressive disorder. We investigated the effect of ketamine on accelerating the antidepressant efficacy of ECT. Methods One hundred twenty-seven patients with major depressive disorder were included in this randomized, placebo-controlled, double-blind study. The study group received 0.3 mg/kg ketamine, and the control group received an isovolumetric dose of normal saline before undergoing ECT under propofol anesthesia. The main outcome was the H...
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research
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