Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.

CONCLUSION: The prevalence of T-risk allele for the TCF7L2 rs7903146 prevailed in the late time-to-glucose peak group, which in turn is associated with impaired β-cell responsiveness to glucose (φ), thereby predisposing to prediabetes and diabetes in obese youths. PMID: 31972003 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31972003?dopt=Abstract

Source: The Journal of Clinical Endocrinology and Metabolism - January 25, 2020 Category: Endocrinology Authors: Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S Tags: J Clin Endocrinol Metab Source Type: research