MicroRNA-126 upregulation, induced by training, plays a role in controlling microcirculation in dexamethasone treated rats

Publication date: Available online 25 January 2020Source: Molecular and Cellular EndocrinologyAuthor(s): Naiara A. Herrera, Francine Duchatsch, Lidieli P. Tardelli, Thiago J. Dionísio, Andre L. Shinohara, Carlos F. Santos, Sandra L. AmaralAbstractMicrocirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and prevent DEX-induced microvascular rarefaction. Rats underwent training for 8 weeks and then were treated with DEX (50 μg/kg per day, s.c.) for 14 days. Arterial pressure was measured and tibialis anterior (TA) muscle was collected for analyses. DEX induced hypertension concomitantly with capillary density loss (CD, −23.9%) and decrease of VEGF (−43.0%), p-AKT/AKT (−39.6%) and Bcl-2 (−23.0%) and an increase in caspase-3-cleaved protein level (+34.0%) in TA muscle. Training upregulated microRNA-126 expression (+13.1%), prevented VEGF (+61.4%), p-AKT/AKT (+37.7%), Bcl-2 (+7.7%) decrease and caspase-3-cleaved (−23.1%) increase associated with CD (+54.7%) reduction and hypertension prevention. MiRNA-126 upregulation, induced by training, plays a role in controlling microcirculation, which may be a potential target against DEX-induced microvascular rarefaction.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research

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