The profiles of microRNAs from urinary extracellular vesicles (EVs) prepared by various isolation methods and their correlation with serum EV microRNAs

Extracellular vesicles (EVs) have been the focus of intensive studies during the last two decades due to interesting characteristics: (i) active release from cells; (ii) a mode of intercellular communication; and (iii) their potential as disease biomarkers [1 –3]. EVs are formed by direct budding of the plasma membrane (microvesicles) or as intraluminal vesicles within multivesicular bodies, which fuse with the inner plasma membrane for extracellular release (exosomes) [2]. EVs have been shown to contain and transfer nucleic acids, lipids, and proteins to neighboring cells or to the extracellular microenvironment [1–3].

Source: Diabetes Research and Clinical Practice - January 23, 2020 Category: Endocrinology Authors: Sungjin Park, Kiyoung Lee, Ie Byung Park, Nan Hee Kim, Seongcheol Cho, Won Jong Rhee, Yujin Oh, Jimin Choi, Seungyoon Nam, Dae Ho Lee Source Type: research