Phyllanthus acidus (L.) Skeels: A review of its traditional uses, phytochemistry, and pharmacological properties

ConclusionAlthough P. acidus has been proven as a valuable medicinal source from its traditional uses. However, the pharmacological experiments conducted were not sufficient to verify its traditional uses. More investigation is required to confirm the traditional claims such as bioassay-guided isolation of bioactive compounds, detailed pharmacological investigations, clinical studies, and its toxicity investigation. Additionally, an experimental design with sufficient data replication, the use of controls and authenticated research materials, and the selection of a rationale dose or concentration for the analysis are keys to providing reproducible experimental data.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 7 January 2020Source: Journal of EthnopharmacologyAuthor(s): Diana Giles-Rivas, Samuel Estrada-Soto, A. Berenice Aguilar-Guadarrama, Julio Almanza-Pérez, Sara García-Jiménez, Blanca Colín-Lozano, Gabriel Navarrete-Vázquez, Rafael Villalobos-MolinaAbstractEthnopharmacological importance Cordia morelosanaStandley (Boraginaceae) is commonly used in folk medicine for the treatment of diarrhoea, kidney inflammation, diabetes, lung pain, bronchitis, asthma, hoarseness, cough and fever.AimCurrent work was conducted to develop a bio-guided isolation of antidiabe...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Bronchial thermoplasty (BT) is a bronchoscopic procedure for treating severe asthma using thermal energy to reduce airway smooth muscle. There are some reports of complications such as bronchitis and atelectasis due to transient inflammation and oedema, but, to the best of our knowledge, no studies have reported eosinophilic pneumonia (EP) due to BT. Mepolizumab is an anti ‐interleukin‐5 monoclonal antibody that is reportedly effective against eosinophilic inflammation such as bronchial asthma; however, only few studies have reported its use in treating EP. Here, we report the effectiveness of mepolizumab in treating E...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conclusion: We present a risk estimation tool for COPD patients in an easy-to-use format suitable for clinicians in daily clinical practice.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Introduction: Nutritional status change in chronic respiratory diseases (CPD) in terms of fat tissue and skeletal muscles. Overweight pts have better prognosis than cachectic pts. Preserving skeletal muscles is essential for maintaining exercise capacity. First time to ultrasonographically assess peritoneal fat (PF), mid-thigh fat (MTF) and mid-thigh muscles (MTM) in chronic respiratory pts.Objectives: If any correlation between PF, MTF and MTM in a lot of 125 consecutive chronic respiratory pts.Methods: 125 chronic respiratory pts (mean age 63.72; SD 13.87; M 60/48%; F 65/52%; IPF 54/43.2%; COPD 34/27.2%; chronic bronchit...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Introduction: Patients with chronic obstructive pulmonary disease (COPD) have higher risk of hospitalization for cardiovascular events (CVE). An association between influenza infection and myocardial infarction (MI) is established. Our objective is to evaluate the COPD as an additional risk factor for CVE and respiratory events (RE) in patients with respiratory viral infection.Methods: We performed a retrospective cross-sectional analysis of 139 patients, with positive PCR for respiratory viruses in January of 2018. Cardiovascular risk factors (CVRF) (hypertension, diabetes, dyslipidemia and smoking) and medical history we...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
ConclusionsOSCS is a rare disorder. Diagnosis can often be challenging because other diseases, such as osteopetrosis, pyknodysostosis, Paget disease of bone, and other sclerosing bone dysplasias, make this difficult to diagnose. Radiologists should be aware of the specific radiographic appearance of this condition to aid in the proper diagnosis and management of these patients.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
It’s hard to overstate the dangers of smoking. Nearly 500,000 people die of tobacco-related disease each year in the US. Over the next decade, estimates are that around eight million people will die prematurely worldwide each year due to tobacco use. The list of tobacco-related diseases and conditions is long and growing. It includes: cardiovascular disease, including heart attack and stroke emphysema, bronchitis, and asthma lung and other types of cancer tooth decay weathering of the skin having a low-birthweight baby diabetes eye damage (including cataracts and macular degeneration). And there are others. The poi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Prevention Smoking cessation Source Type: blogs
Conclusion: The results from this study will provide information to aid the development of prevention and intervention strategies for Aboriginal communities. PMID: 30584428 [PubMed - in process]
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
Aim: Clarify the cause-effect relationship between COPD and type 2 diabetes mellitus (DM2) and assess the prevalence of latent carbohydrate metabolism disorders in COPD patients.Material and methods: In a multicentral study, a retrospective cohort analysis of the reciprocal reported prevalence of COPD (300) and diabetes mellitus type 2 (DM2) (400 patients) was performed, and an oral glucose tolerance test (OGTT) was performed in 40 patients with COPD without obesity with normal indicators of sugar in the blood on an empty stomach. As a control, population indices were used, and in the estimation of OGTT in COPD patients, t...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found...
Source: PLOS Currents Disasters - Category: International Medicine & Public Health Authors: Source Type: research
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